2022
Alloimmunization following antigen‐negative red blood cell transfusion
Jacobs J, Binns T, Abels E, Iyer K, Villalba C, Verma A, Sostin N, Tormey C. Alloimmunization following antigen‐negative red blood cell transfusion. Transfusion 2022, 63: 430-434. PMID: 36458330, DOI: 10.1111/trf.17208.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsBlood Group AntigensBlood TransfusionErythrocyte TransfusionErythrocytesFemaleHumansIsoantibodiesPregnancyConceptsTransfusion of RBCsRed blood cell transfusionRed blood cell alloimmunizationPrevious antigen exposureBlood cell transfusionAlloantibody specificitiesCell transfusionRBC transfusionAntigen exposureRBC alloantibodiesAntigenic stimulusDetectable titersAntigenic stimulationMyeloid neoplasmsTransfusionAlloantibodiesAlloimmunizationParticular antigenPrior exposureStimulatory eventsExact mechanismCorresponding antibodiesRBCsExposurePregnancy
2021
Development of anti-Jk3 associated with silenced Kidd antigen expression and a novel single nucleotide variant of the JK gene
Manrai PA, Siddon AJ, Hager KM, Hendrickson JE, Keller MA, Tormey CA. Development of anti-Jk3 associated with silenced Kidd antigen expression and a novel single nucleotide variant of the JK gene. Immunohematology 2021, 37: 109-112. PMID: 34591379, DOI: 10.21307/immunohematology-2021-015.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlood Group AntigensExonsFemaleHumansKidd Blood-Group SystemMiddle AgedNucleotidesConceptsHigh-prevalence antigenReagent red blood cellsDirect antiglobulin testBlood samplesBlood group APatient blood samplesImmunohematology reference laboratoryRare alloantibodyRed blood cellsOncologic careAntiglobulin testGroup APolynesian descentBlood cellsNon-conservative amino acid changeSingle nucleotide variantsReference laboratoryAmino acid changesFamilial backgroundExon 8Antigen expressionExon 7Nucleotide variantsAcid changesExon 4
2019
Microbial pathogen primary sequence inversely correlates with blood group antigen immunogenicity
Baine I, Bahar B, Hendrickson JE, Hudson KE, Tormey CA. Microbial pathogen primary sequence inversely correlates with blood group antigen immunogenicity. Transfusion 2019, 59: 1651-1656. PMID: 30811034, DOI: 10.1111/trf.15212.Peer-Reviewed Original Research
2018
Risk factors for red blood cell alloimmunization in the Recipient Epidemiology and Donor Evaluation Study (REDS‐III) database
Karafin MS, Westlake M, Hauser RG, Tormey CA, Norris PJ, Roubinian NH, Wu Y, Triulzi DJ, Kleinman S, Hendrickson JE, Study‐III N. Risk factors for red blood cell alloimmunization in the Recipient Epidemiology and Donor Evaluation Study (REDS‐III) database. British Journal Of Haematology 2018, 181: 672-681. PMID: 29675950, PMCID: PMC5991618, DOI: 10.1111/bjh.15182.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnemia, Sickle CellArthritis, RheumatoidBlood DonorsBlood Group AntigensChildChild, PreschoolDatabases, FactualErythrocyte TransfusionFemaleHumansImmunizationInfantIsoantibodiesLupus Erythematosus, SystemicMaleMiddle AgedMyelodysplastic SyndromesRisk FactorsTransfusion ReactionConceptsRed blood cell alloimmunizationRecipient EpidemiologyRecipients databaseSignificant RBC alloantibodiesNegative antibody screenLargest RBCStandardized registryPositive patientsRBC alloantibodiesAntibody screenICD9/10 codesPatient cohortRisk factorsResponder statusCertain diagnosisBlood typeLarger studyAlloimmunizationRhD statusStudy databaseRespondersPatientsDisease associationsPotential correlatesEpidemiology
2017
A novel association between high red blood cell alloimmunization rates and hereditary hemorrhagic telangiectasia
Zheng Y, Pollak J, Henderson K, Hendrickson JE, Tormey CA. A novel association between high red blood cell alloimmunization rates and hereditary hemorrhagic telangiectasia. Transfusion 2017, 58: 775-780. PMID: 29210083, DOI: 10.1111/trf.14451.Peer-Reviewed Original ResearchMeSH KeywordsBlood Group AntigensErythrocyte TransfusionFemaleHumansIsoantibodiesMaleTelangiectasia, Hereditary HemorrhagicTransfusion ReactionConceptsHereditary hemorrhagic telangiectasiaRBC alloimmunization rateAlloimmunization rateHHT patientsRBC transfusionHemorrhagic telangiectasiaRed blood cell transfusionProphylactic antigen matchingBlood cell transfusionTertiary care facilityMultiple arteriovenous malformationsAutosomal dominant disorderCommon alloantibodiesHHT populationCell transfusionSurgical bleedingTransfusion burdenAntigen matchingSpontaneous hemorrhageRetrospective studyMedical recordsArteriovenous malformationsCare facilitiesPatientsDisease pathophysiology
2016
Detection rate of blood group alloimmunization based on real‐world testing practices and kinetics of antibody induction and evanescence
Stack G, Tormey CA. Detection rate of blood group alloimmunization based on real‐world testing practices and kinetics of antibody induction and evanescence. Transfusion 2016, 56: 2662-2667. PMID: 27394029, DOI: 10.1111/trf.13704.Peer-Reviewed Original ResearchConceptsAntibody inductionAntibody testingAlloantibody detectionRed blood cell transfusionNon-ABO antibodiesBlood cell transfusionGeneral hospital settingBlood group alloantibodiesDetection rateRBC infusionCell transfusionRBC transfusionAntibody screenDays posttransfusionMismatched transfusionHospital settingTransfusionHemolytic reactionRBC unitsStudy designTesting practicesAlloantibodiesAlloimmunizationPatientsOne-thirdEstimating the immunogenicity of blood group antigens: a modified calculation that corrects for transfusion exposures
Stack G, Tormey CA. Estimating the immunogenicity of blood group antigens: a modified calculation that corrects for transfusion exposures. British Journal Of Haematology 2016, 175: 154-160. PMID: 27340943, DOI: 10.1111/bjh.14175.Peer-Reviewed Original ResearchMeSH KeywordsAntibody SpecificityBlood Group AntigensHumansImmunityImmunoglobulin GIsoantibodiesModels, StatisticalTransfusion ReactionConceptsAntigen immunogenicityPre-existing antibodiesLow-frequency antigensMean RBCHigh-frequency antigensHospital transfusion servicesTransfusion exposureAntibody frequencyAntigen exposureRBC exposureTransfusion servicesImmunogenicityRBC unitsAntigenPatientsBlood groupReference antigenUnit exposureExposureFold increaseSmall increaseThe Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice
Gibb DR, Calabro S, Liu D, Tormey CA, Spitalnik SL, Zimring JC, Hendrickson JE, Hod EA, Eisenbarth SC. The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice. EBioMedicine 2016, 9: 77-86. PMID: 27345021, PMCID: PMC4972549, DOI: 10.1016/j.ebiom.2016.06.008.Peer-Reviewed Original ResearchConceptsRBC transfusionNLRP3 inflammasomeRed blood cell transfusionInnate immune cell activationPro-inflammatory pathogensMolecular patternsBlood cell transfusionProduction of alloantibodiesTransfusion-associated mortalityImmune cell activationInnate immune stimuliBlood group antigensBone marrow failureAlloantibody productionRBC alloimmunizationAlloantibody responsesCell transfusionAlloimmune responseRed blood cellsABO matchingImmunological factorsInflammatory conditionsLeading causeImmune stimuliEndogenous DAMPRed Blood Cell Antibodies in Hematology/Oncology Patients Interpretation of Immunohematologic Tests and Clinical Significance of Detected Antibodies
Hendrickson JE, Tormey CA. Red Blood Cell Antibodies in Hematology/Oncology Patients Interpretation of Immunohematologic Tests and Clinical Significance of Detected Antibodies. Hematology/Oncology Clinics Of North America 2016, 30: 635-651. PMID: 27113001, DOI: 10.1016/j.hoc.2016.01.006.Peer-Reviewed Original ResearchMeSH KeywordsAnemia, Hemolytic, AutoimmuneBlood BanksBlood Group AntigensBlood Group IncompatibilityErythrocytesHumansIsoantibodiesNeoplasmsTransfusion ReactionConceptsRed blood cell transfusionRed blood cell antibodiesRBC alloimmunization rateBlood cell transfusionManagement of patientsDevelopment of alloantibodiesBlood group antigensAlloimmunization rateRBC alloimmunizationSuch alloantibodiesCell transfusionCell antibodiesClinical significanceHemolytic anemiaPatients' interpretationsDetected antibodiesTransfusionGroup antigensBlood bankCompatible unitsAntibodiesAlloantibodiesOncology disordersDeleterious consequencesAlloimmunization
2015
Molecular immunohaematology round table discussions at the AABB Annual Meeting, Philadelphia 2014.
Flegel WA, De Castilho SL, Keller MA, Klapper EB, Moulds JM, Noizat-Pirenne F, Shehata N, Stack G, St-Louis M, Tormey CA, Waxman DA, Weinstock C, Wendel S, Denomme GA. Molecular immunohaematology round table discussions at the AABB Annual Meeting, Philadelphia 2014. Blood Transfusion = Trasfusione Del Sangue 2015, 14: 425-33. PMID: 26710354, PMCID: PMC5016302, DOI: 10.2450/2015.0130-15.Peer-Reviewed Original Research
2014
Molecular immunohaematology round table discussions at the AABB Annual Meeting, Denver 2013.
Flegel WA, Castilho L, Delaney M, Klapper EB, Moulds JM, Noizat-Pirenne F, Shehata N, Stack G, Tormey CA, Wagner FF, Waxman DA, Weinstock C, Wendel S, Denomme GA. Molecular immunohaematology round table discussions at the AABB Annual Meeting, Denver 2013. Blood Transfusion = Trasfusione Del Sangue 2014, 13: 514-20. PMID: 25545874, PMCID: PMC4614304, DOI: 10.2450/2014.0213-14.Peer-Reviewed Original Research
2013
Antibodies of undetermined significance: nuisance or near miss?
Tormey CA, Hendrickson JE. Antibodies of undetermined significance: nuisance or near miss? Transfusion 2013, 53: 926-928. PMID: 23659526, DOI: 10.1111/trf.12147.Peer-Reviewed Original Research
2009
Immunogenicity of blood group antigens: a mathematical model corrected for antibody evanescence with exclusion of naturally occurring and pregnancy-related antibodies
Tormey CA, Stack G. Immunogenicity of blood group antigens: a mathematical model corrected for antibody evanescence with exclusion of naturally occurring and pregnancy-related antibodies. Blood 2009, 114: 4279-4282. PMID: 19713462, DOI: 10.1182/blood-2009-06-227793.Peer-Reviewed Original ResearchMeSH KeywordsBlood Group AntigensFemaleHumansImmunity, InnateIsoantibodiesMaleMathematical ConceptsModels, ImmunologicalPregnancyTransfusion ReactionIMMUNOHEMATOLOGY: The characterization and classification of concurrent blood group antibodies
Tormey CA, Stack G. IMMUNOHEMATOLOGY: The characterization and classification of concurrent blood group antibodies. Transfusion 2009, 49: 2709-2718. PMID: 19682334, DOI: 10.1111/j.1537-2995.2009.02337.x.Peer-Reviewed Original ResearchConceptsBlood group antibodiesGroup antibodiesVeterans Affairs Medical CenterAntigenic specificityAlloimmunized individualsConcurrent antibodiesAntibody persistenceTransfusion recordsAntibody screenAlloimmunized patientsTime of disappearanceMedical CenterPatientsBG antibodyStudy designAntibody specificityAntibodiesAlloantibodiesAlloimmunizationAntibody pairsCompatibility testingSpecificityMost casesEstimation of Combat-Related Blood Group Alloimmunization and Delayed Serologic Transfusion Reactions in U.S. Military Veterans
Tormey CA, Stack G. Estimation of Combat-Related Blood Group Alloimmunization and Delayed Serologic Transfusion Reactions in U.S. Military Veterans. Military Medicine 2009, 174: 503-507. PMID: 20731281, DOI: 10.7205/milmed-d-02-5808.Peer-Reviewed Original ResearchConceptsSerologic transfusion reactionsTransfusion reactionsVeterans Affairs Medical CenterAnamnestic immune responseMilitary veteran patientsBlood group alloantibodiesMilitary veteransPre-existing antibodiesU.S. military veteransAlloimmunization ratePrior alloimmunizationVeteran patientsTransfusion recordsVA careImmune responseMedical CenterAlloimmunizationAlloantibodiesVeteransAntibodiesHigh rateTransfusionPatientsPrevalenceCareThe persistence and evanescence of blood group alloantibodies in men
Tormey CA, Stack G. The persistence and evanescence of blood group alloantibodies in men. Transfusion 2009, 49: 505-512. PMID: 19040411, DOI: 10.1111/j.1537-2995.2008.02014.x.Peer-Reviewed Original ResearchConceptsBlood group alloantibodiesVeterans Affairs Medical CenterInitial negative testingTransfusion service recordsTransfusion-related alloimmunizationDuration of followHemolytic transfusion reactionsMonths of detectionFirst antibodyMale patientsTransfusion reactionsMedical CenterAlloantibodiesNegative testingAntibody detectionYear of inductionStudy designAntigenic specificityAntibodiesMilitary veteransPatientsMore yearsTwo-thirdsService recordsMen
2008
Red blood cell alloantibody frequency, specificity, and properties in a population of male military veterans
Tormey CA, Fisk J, Stack G. Red blood cell alloantibody frequency, specificity, and properties in a population of male military veterans. Transfusion 2008, 48: 2069-2076. PMID: 18631165, DOI: 10.1111/j.1537-2995.2008.01815.x.Peer-Reviewed Original ResearchConceptsRBC alloantibodiesMale military veteransDecade of birthMilitary veteransVA careRed blood cell alloantibodiesVeterans Affairs Medical CenterHospital-based patientsPercent of casesLarge male predominanceRace/ethnicityAlloantibody frequenciesAlloantibody specificitiesFrequent alloantibodiesTransfusion historyMale predominanceD alloimmunizationTransfusion recordsHigh prevalenceMedical CenterAlloantibodiesAntibody developmentAlloimmunizationAntiglobulin phasePrevalence