2019
Red blood cell alloimmunization is associated with lower expression of FcγR1 on monocyte subsets in patients with sickle cell disease
Balbuena‐Merle R, Curtis SA, Devine L, Gibb DR, Karafin MS, Luckey CJ, Tormey CA, Siddon AJ, Roberts JD, Hendrickson JE. Red blood cell alloimmunization is associated with lower expression of FcγR1 on monocyte subsets in patients with sickle cell disease. Transfusion 2019, 59: 3219-3227. PMID: 31355970, PMCID: PMC7075520, DOI: 10.1111/trf.15463.Peer-Reviewed Original ResearchConceptsSickle cell diseaseMonocyte subsetsTotal monocytesCell diseaseComplications of SCDRed blood cell alloimmunizationRed blood cell alloantibodiesElectronic medical recordsTransfusion exposureSerum cytokinesIntermediate monocytesRBC alloantibodiesInflammatory milieuCD64 expressionClassical monocytesPeripheral bloodInflammatory functionsMedical recordsAntibody formationClinical significancePatientsMonocytesFlow cytometryLow expressionResponders
2016
Two approaches to the clinical dilemma of treating TTP with therapeutic plasma exchange in patients with a history of anaphylactic reactions to plasma
Sidhu D, Snyder EL, Tormey CA. Two approaches to the clinical dilemma of treating TTP with therapeutic plasma exchange in patients with a history of anaphylactic reactions to plasma. Journal Of Clinical Apheresis 2016, 32: 158-162. PMID: 27246502, DOI: 10.1002/jca.21475.Peer-Reviewed Original ResearchConceptsTherapeutic plasma exchangeThrombotic thrombocytopenic purpuraSevere allergic reactionsAnaphylactic reactionsTTP exacerbationTTP remissionTreatment strategiesAllergic reactionsVon Willebrand factor (VWF) cleaving proteasePotential treatment strategyPossible treatment protocolReplacement plasmaAdverse eventsAcute treatmentPlasma exchangeThrombocytopenic purpuraSimilar patientsClinical dilemmaTreatment protocolAllergic riskPatientsDonor plasmaADAMTS-13Plasma productsStandard plasma
2015
Complex regional pain syndrome and dysautonomia in a 14‐year‐old girl responsive to therapeutic plasma exchange
Hendrickson JE, Hendrickson ET, Gehrie EA, Sidhu D, Wallukat G, Schimke I, Tormey CA. Complex regional pain syndrome and dysautonomia in a 14‐year‐old girl responsive to therapeutic plasma exchange. Journal Of Clinical Apheresis 2015, 31: 368-374. PMID: 26011726, DOI: 10.1002/jca.21407.Peer-Reviewed Original ResearchConceptsComplex regional pain syndromeTherapeutic plasma exchangeCRPS patientsLambert-Eaton myasthenic syndromeReflex sympathetic dystrophyRegional pain syndromeMuscarinic M2 receptorsΒ2-adrenergicAdditional immunosuppressionDetectable autoantibodiesLeg painNeuronal surface receptorsPain syndromeSympathetic dystrophyClinical responseVasomotor symptomsMyasthenia gravisReceptor autoantibodiesAppropriate therapyM2 receptorsPlasma exchangeAlbumin replacementMultiple therapiesEffective therapyMyasthenic syndrome
2008
Acute vancomycin-dependent immune thrombocytopenia as an anamnestic response
Kenney B, Tormey CA. Acute vancomycin-dependent immune thrombocytopenia as an anamnestic response. Platelets 2008, 19: 379-383. PMID: 18791945, DOI: 10.1080/09537100802082280.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAmputation, SurgicalAnti-Bacterial AgentsAntigens, Human PlateletAutoantibodiesBacteremiaCeftazidimeDrug Therapy, CombinationFoot DiseasesGram-Positive Bacterial InfectionsHumansImmunoglobulin GImmunoglobulin MImmunologic MemoryMaleMiddle AgedPurpura, Thrombocytopenic, IdiopathicSurgical Wound InfectionVancomycinConceptsAntibiotic therapyPlatelet antibodiesPlatelet countPlatelet destructionAdverse bleeding eventsAnamnestic antibody responseDrug-related thrombocytopeniaNew onset thrombocytopeniaRapid platelet destructionAnti-platelet antibodiesNormal platelet countCases of thrombocytopeniaSafe drug useBleeding eventsVancomycin administrationWet gangreneImmune thrombocytopeniaImmediate discontinuationRare complicationMale patientsAnamnestic responseDrug withdrawalSevere thrombocytopeniaAcute reductionPrior sensitization