2020
The use of 4F‐PCC to correct direct oral anticoagulant‐induced coagulopathy: An observational analysis
Zheng Y, Tormey CA. The use of 4F‐PCC to correct direct oral anticoagulant‐induced coagulopathy: An observational analysis. Transfusion Medicine 2020, 30: 304-307. PMID: 32342588, DOI: 10.1111/tme.12683.Peer-Reviewed Original ResearchConceptsDirect oral anticoagulantsThromboembolic eventsFour-factor prothrombin complex concentrateLevel 1 trauma centerAdditional prospective studiesRetrospective observational studyProthrombin complex concentrateOff-label useEmergent surgeryOral anticoagulantsMost patientsClinical outcomesTrauma centerHgb levelsProspective studyLabel indicationsComplex concentrateSevere hemorrhageObservational studyHemorrhage sizePatientsCoagulopathyAdministrationBleedingHemorrhage
2016
Successful Use of Four Factor-Prothrombin Complex Concentrate for Congenital Factor X Deficiency in the Setting of Neurosurgery
Siddon AJ, Tormey CA. Successful Use of Four Factor-Prothrombin Complex Concentrate for Congenital Factor X Deficiency in the Setting of Neurosurgery. Lab Medicine 2016, 47: e35-e37. PMID: 27378481, PMCID: PMC4985779, DOI: 10.1093/labmed/lmw037.Peer-Reviewed Original ResearchConceptsCongenital factor X deficiencyFactor X deficiencyX deficiencyExcessive bleedingComplex concentrateFour-factor prothrombin complex concentrateFactor prothrombin complex concentrateFirst-line therapyAnterior cervical discectomySetting of traumaProthrombin complex concentrateFresh frozen plasmaRare coagulation disorderMajor neurosurgeryCervical discectomyThromboembolic complicationsSpontaneous hemorrhageCoagulation disordersFrozen plasmaInvasive proceduresOperative casesBleedingWhite menDeficiencyDisorders
2014
Clinical Applications of 4-Factor Prothrombin Complex Concentrate: A Practical Pathologist's Perspective
Unold D, Tormey CA. Clinical Applications of 4-Factor Prothrombin Complex Concentrate: A Practical Pathologist's Perspective. Archives Of Pathology & Laboratory Medicine 2014, 139: 1568-75. PMID: 26619030, DOI: 10.5858/arpa.2014-0366-rs.Peer-Reviewed Original ResearchConceptsProthrombin complex concentrateOral anticoagulantsComplex concentrateVitamin K antagonist reversalVitamin K antagonist therapyNovel oral anticoagulantsSpecific reversal agentsTreatment of hemorrhageDependent coagulation factorsAntagonist therapyLiver diseaseLabel indicationsAntagonist reversalTherapeutic dosesReversal agentsCoagulation factorsBleeding disorderRare coagulopathyVitamin KBlood bankersPathologist's perspectiveClinical applicationAnticoagulantsCoagulopathyBleeding