HbA1c and brain health across the entire glycaemic spectrum
Garfield V, Farmaki A, Eastwood SV, Mathur R, Rentsch CT, Bhaskaran K, Smeeth L, Chaturvedi N. HbA1c and brain health across the entire glycaemic spectrum. Diabetes Obesity And Metabolism 2021, 23: 1140-1149. PMID: 33464682, PMCID: PMC8261644, DOI: 10.1111/dom.14321.Peer-Reviewed Original ResearchConceptsVascular dementiaHippocampal volumeGlycaemic spectrumBrain healthWMH volumeAlzheimer's dementiaAD riskCognitive declineWhite matter hyperintensity volumeIncident vascular dementiaLower WMH volumeHigher WMH volumeGreater hippocampal volumeBrain health outcomesLower hippocampal volumeUK Biobank cohortGlycaemic categoriesKnown diabetesAntihypertensive medicationsHbA1c levelsCause dementiaCertain cardiovascular drugsExcess riskNormoglycaemic individualsHyperintensity volume