T102. IDENTIFYING NEW TREATMENT TARGETS FOR ALCOHOL USE DISORDER THROUGH GENETIC AND ELECTRONIC HEALTH RECORDS DATA APPROACHES
Gray J, Kranzler H, Leggio L, Piserchia Z, Winterlind E, Setzer M, Rentsch C. T102. IDENTIFYING NEW TREATMENT TARGETS FOR ALCOHOL USE DISORDER THROUGH GENETIC AND ELECTRONIC HEALTH RECORDS DATA APPROACHES. European Neuropsychopharmacology 2023, 75: s217. DOI: 10.1016/j.euroneuro.2023.08.386.Peer-Reviewed Original ResearchSeed genesGenome-wide significant lociL-type calcium channel blockerDisease-associated genesCalcium channel blockersAlcohol use disorderTargets of approved drugsPeripheral genesSignificant lociCausal genesGene identificationGene inputNetwork genesGenetic supportBiological networksChannel blockersGenesUse disorderDisease mechanismsFDA-approved drugsL-type calcium channelsRegulate dopamine activityImprove drug developmentAlpha-adrenergic receptorsSevere side effects