2022
Standardization of presurgical language fMRI in Greek population: Mapping of six critical regions
Gkiatis K, Garganis K, Benjamin CF, Karanasiou I, Kondylidis N, Harushukuri J, Matsopoulos GK. Standardization of presurgical language fMRI in Greek population: Mapping of six critical regions. Brain And Behavior 2022, 12: e2609. PMID: 35587046, PMCID: PMC9226851, DOI: 10.1002/brb3.2609.Peer-Reviewed Original ResearchConceptsLanguage mappingFunctional magnetic resonance imagingPresurgical language mappingMother tongueLanguage systemWernicke-LichtheimLanguage regionsLanguage functional magnetic resonance imagingGreekLanguage lateralizationHealthy right-handed volunteersGreek populationRight-handed volunteersMagnetic resonance imagingClinical setupEloquent cortexFMRI acquisitionContralateral cerebellumPresurgical evaluationAppropriate tasksGreek patientsWada testResonance imagingNoninvasive alternativeFMRI protocolResponse to "Letter to the Editor. The weight of functional MRI to predict surgery-induced risk after tumor resection: enough to be safe?"
Połczyńska M, Benjamin C, Bookheimer S. Response to "Letter to the Editor. The weight of functional MRI to predict surgery-induced risk after tumor resection: enough to be safe?". Journal Of Neurosurgery 2022, 137: 314-315. PMID: 39314541, PMCID: PMC11419400.Peer-Reviewed Original Research
2021
Cognitive Biomarkers in the Clinic: Lessons From Presurgical fMRI
Benjamin CFA. Cognitive Biomarkers in the Clinic: Lessons From Presurgical fMRI. Journal Of Clinical Neurophysiology 2021, 39: 121-128. PMID: 34366397, DOI: 10.1097/wnp.0000000000000834.Peer-Reviewed Original ResearchGerstmann Syndrome Deconstructed by Cortical Stimulation
Vaddiparti A, McGrath H, Benjamin C, Sivaraju A, Spencer DD, Hirsch LJ, Damisah E, Quraishi IH. Gerstmann Syndrome Deconstructed by Cortical Stimulation. Neurology 2021, 97: 420-422. PMID: 34187861, PMCID: PMC9246017, DOI: 10.1212/wnl.0000000000012441.Peer-Reviewed Original ResearchTumor location and reduction in functional MRI estimates of language laterality
Połczyńska MM, Beck L, Kuhn T, Benjamin CF, Ly TK, Japardi K, Cavanagh L, Bookheimer SY. Tumor location and reduction in functional MRI estimates of language laterality. Journal Of Neurosurgery 2021, 135: 1674-1684. PMID: 33799298, PMCID: PMC8909357, DOI: 10.3171/2020.9.jns202036.Peer-Reviewed Original ResearchRight hemisphere tumorsAnterior tumorsHemisphere tumorsLaterality indexLanguage lateralityBroca's areaFMRI laterality indicesLeft hemisphere tumorsPosterior ROIsWhole-brain levelPosterior tumorsTumor locationTumor resectionPreoperative fMRIInferior frontal gyrusTumor groupLanguage cortexBrain tumorsPatientsNumerous confoundersTumor hemisphereConfoundersRegion of interestLeft inferior frontal gyrusTumorsElectrical cortical stimulation can impair production of the alphabet without impairing counting
Rojas PH, Sivaraju A, Quraishi IH, Vanderlind M, Rofes A, Połczynska-Bletsos MM, Spencer DD, Hirsch LJ, Benjamin CFA. Electrical cortical stimulation can impair production of the alphabet without impairing counting. Epilepsy & Behavior Reports 2021, 15: 100433. PMID: 33778464, PMCID: PMC7985277, DOI: 10.1016/j.ebr.2021.100433.Peer-Reviewed Case Reports and Technical NotesElectrical stimulation mappingCortical electrical stimulation mappingDrug-resistant focal epilepsyPatient experienced lossDrug-resistant epilepsyElectrical cortical stimulationLanguage-dominant hemisphereSuperior temporal gyrusPosterior superior temporal gyrusCortical stimulationFocal epilepsyStimulation mappingDominant hemispherePatientsTemporal gyrusSelective impairmentLanguage functionEpilepsyExperienced lossImpairmentBrainRiskLanguage impairmentSurgerySole means
2020
Presurgical Language fMRI in Epilepsy: An Introduction
Benjamin C, Gkiatis K, Matsopoulos G, Garganis K. Presurgical Language fMRI in Epilepsy: An Introduction. Contemporary Clinical Neuroscience 2020, 205-239. DOI: 10.1007/978-3-030-35687-3_10.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingLanguage functional magnetic resonance imagingClinical toolMagnetic resonance imagingBrain-behavior relationshipsEpilepsyResonance imagingCognitive AssessmentClinical contextBrain correlatesClinical reportingLanguage areasLanguage declineNeurosurgeryStatistical analysisCortex
2019
Comorbidity of reading disabilities and ADHD: Structural and functional brain characteristics
Langer N, Benjamin C, Becker BLC, Gaab N. Comorbidity of reading disabilities and ADHD: Structural and functional brain characteristics. Human Brain Mapping 2019, 40: 2677-2698. PMID: 30784139, PMCID: PMC6508987, DOI: 10.1002/hbm.24552.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderFunctional magnetic resonance imagingGroup differencesMultiple deficit modelFunctional brain characteristicsWhole-brain analysisOverall group differencesComprehensive behavioral testingCommon developmental disorderPhonological processingFMRI taskExecutive functionNeural correlatesHyperactivity disorderNeural mechanismsSame paradigmClinical groupsDevelopmental disordersDeficit modelBrain characteristicsBrain structuresInterest analysisBrain alterationsBehavioral testingChildren
2018
Presurgical language fMRI: Technical practices in epilepsy surgical planning
Benjamin CFA, Dhingra I, Li AX, Blumenfeld H, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen RA, Warfield SK, Peters JM, Reutens D, Połczyńska MM, Hirsch LJ, Spencer DD. Presurgical language fMRI: Technical practices in epilepsy surgical planning. Human Brain Mapping 2018, 39: 4032-4042. PMID: 29962111, PMCID: PMC6175127, DOI: 10.1002/hbm.24229.Peer-Reviewed Original ResearchConceptsLanguage functional MRIFunctional MRISurgical planningEpilepsy surgical planningEpilepsy surgical programsGeneral linear modelingBlood flowClinical practicePatient careSurgical programsRoutine useMarked heterogeneityClinical applicationVerbal fluencyData highlightFMRI dataMost programsPatientsWidespread useEpilepsyIndividualsMRICareBrief History of Electrical Cortical Stimulation: A Journey in time from Volta to Penfield (P5.299)
Isitan C, Benjamin C, Quraishi I, Spencer D, Alkawadri R. Brief History of Electrical Cortical Stimulation: A Journey in time from Volta to Penfield (P5.299). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p5.299.Peer-Reviewed Original ResearchPresurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning
Benjamin CFA, Li AX, Blumenfeld H, Constable RT, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen R, Warfield SK, Peters JM, Reutens D, Połczyńska M, Spencer DD, Hirsch LJ. Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning. Human Brain Mapping 2018, 39: 2777-2785. PMID: 29528160, PMCID: PMC6033659, DOI: 10.1002/hbm.24039.Peer-Reviewed Original ResearchConceptsLanguage functional MRISurgical marginsFunctional MRIPatient outcomesClinical practiceEpilepsy surgical planningEpilepsy surgical programsCurrent clinical practiceDirect brain stimulationEpilepsy surgeryStimulation mappingBrain stimulationClinical teamLanguage lateralizationSurgical programsSurgical planningLanguage-critical areasFMRI findingsFMRI paradigmUnexpected preservationFurther validationLanguage declineAdultsOutcomesChildrenCorrection: Behavioral and Neural Correlates of Executive Functioning in Musicians and Non-Musicians
Zuk J, Benjamin C, Kenyon A, Gaab N. Correction: Behavioral and Neural Correlates of Executive Functioning in Musicians and Non-Musicians. PLOS ONE 2018, 13: e0191394. PMID: 29324890, PMCID: PMC5764450, DOI: 10.1371/journal.pone.0191394.Peer-Reviewed Original Research
2017
Impairment of consciousness induced by bilateral electrical stimulation of the frontal convexity
Quraishi IH, Benjamin CF, Spencer DD, Blumenfeld H, Alkawadri R. Impairment of consciousness induced by bilateral electrical stimulation of the frontal convexity. Epilepsy & Behavior Reports 2017, 8: 117-122. PMID: 29204347, PMCID: PMC5707211, DOI: 10.1016/j.ebcr.2017.09.006.Peer-Reviewed Case Reports and Technical NotesElectrical cortical stimulationLoss of consciousnessCortical stimulationFrontal convexityFocal cortical stimulationIntracranial EEG evaluationBilateral electrical stimulationImpairment of consciousnessCessation of stimulationLateral frontal lobeFronto-parietal areasIntractable epilepsyIctal dischargesRarity of reportsElectrophysiological findingsFocal epilepsyEpileptic focusEEG evaluationIntracranial EEG recordingsCase of impairmentCortical connectivityElectrical stimulationEpileptic seizuresFrontal lobeSubcortical structuresImproving language mapping in clinical fMRI through assessment of grammar
Połczyńska M, Japardi K, Curtiss S, Moody T, Benjamin C, Cho A, Vigil C, Kuhn T, Jones M, Bookheimer S. Improving language mapping in clinical fMRI through assessment of grammar. NeuroImage Clinical 2017, 15: 415-427. PMID: 28616382, PMCID: PMC5458087, DOI: 10.1016/j.nicl.2017.05.021.Peer-Reviewed Original ResearchConceptsPre-operative fMRIIntraoperative cortical stimulationLeft hemisphereGood predictive valueHemisphere language dominanceLanguage-dominant hemisphereFunctional magnetic resonanceSurgical candidatesCortical stimulationFMRI testingBrain tumorsDominant hemisphereClinical fMRIPredictive valueBrain surgeryPatientsLanguage mappingStandard testsFMRI activationFMRI protocolFMRI testsRight hemisphereGrammar testRobust activationGroup levelPresurgical language fMRI: Mapping of six critical regions
Benjamin CF, Walshaw PD, Hale K, Gaillard WD, Baxter LC, Berl MM, Polczynska M, Noble S, Alkawadri R, Hirsch LJ, Constable RT, Bookheimer SY. Presurgical language fMRI: Mapping of six critical regions. Human Brain Mapping 2017, 38: 4239-4255. PMID: 28544168, PMCID: PMC5518223, DOI: 10.1002/hbm.23661.Peer-Reviewed Original ResearchConceptsLanguage lateralityWernicke's areaLanguage regionsBasal temporal language areaHum Brain MappTemporal language areaTumor patientsLanguage cortexIndependent cliniciansClinical fMRIExperienced cliniciansCliniciansLanguage mappingLanguage-critical areasSpeech areasAngular gyrusExner's areaLateralityFMRI taskBroca's areaBlind reviewNeurosurgical planningLanguage areasClinical neuropsychologistsFMRI data
2016
Language system organization in a quadrilingual with a brain tumor: Implications for understanding of the language network
Połczyńska MM, Benjamin CF, Japardi K, Frew A, Bookheimer SY. Language system organization in a quadrilingual with a brain tumor: Implications for understanding of the language network. Neuropsychologia 2016, 86: 167-175. PMID: 27143224, DOI: 10.1016/j.neuropsychologia.2016.04.030.Peer-Reviewed Original ResearchConceptsLanguage mappingPre-operative functional magnetic resonance imagingLanguage-specific regionsFunctional magnetic resonance imagingAge of acquisitionIntraoperative language mappingAmount of exposureMultilingual speakersSecond languageFourth languageMultilingual individualsFrontal brain tumorLanguage similarityLanguage systemNeurocognitive modelsLanguageLanguage networkAge 5Different organizationsSpeakersMagnetic resonance imagingResonance imagingImpairmentSystem organizationOrganization
2015
Correction: Behavioral and Neural Correlates of Executive Functioning in Musicians and Non-Musicians
Zuk J, Benjamin C, Kenyon A, Gaab N. Correction: Behavioral and Neural Correlates of Executive Functioning in Musicians and Non-Musicians. PLOS ONE 2015, 10: e0137930. PMID: 26332852, PMCID: PMC4558094, DOI: 10.1371/journal.pone.0137930.Peer-Reviewed Original Research
2014
Grammar tests increase the ability to lateralize language function in the Wada test.
Połczyńska M, Curtiss S, Walshaw P, Siddarth P, Benjamin C, Moseley BD, Vigil C, Jones M, Eliashiv D, Bookheimer S. Grammar tests increase the ability to lateralize language function in the Wada test. Epilepsy Research 2014, 108: 1864-73. PMID: 25270400, DOI: 10.1016/j.eplepsyres.2014.09.014.Peer-Reviewed Original ResearchRole of the Wada test and functional magnetic resonance imaging in preoperative mapping of language and memory: two atypical cases
Połczyńska MM, Benjamin CF, Moseley BD, Walshaw P, Eliashiv D, Vigil C, Jones M, Bookheimer SY. Role of the Wada test and functional magnetic resonance imaging in preoperative mapping of language and memory: two atypical cases. Neurocase 2014, 21: 707-720. PMID: 25372664, DOI: 10.1080/13554794.2014.977300.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonanceWada testAtypical language representationRight-handed individualsLanguage dominanceLanguage lateralizationLanguage representationCognitive deficitsUnexpected memoryWada testingAtypical casesMemoryResective epilepsy surgeryEpilepsy surgeryPreoperative mappingSeizure onsetInvasive proceduresMagnetic resonanceLateralizationDeficitsPotential riskRiskLanguageIndividualsSurgeryElemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy
Benjamin CF, Saling MM, Wood AG, Reutens DC. Elemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy. PLOS ONE 2014, 9: e100891. PMID: 24978828, PMCID: PMC4076213, DOI: 10.1371/journal.pone.0100891.Peer-Reviewed Original ResearchConceptsMTL damageAssociation formationAssociative processingTemporal lobe epilepsyMesial temporal lobe damageNovel fMRI taskCognitive neuropsychological modelGroup whole-brain analysesLeft Temporal Lobe EpilepsyMesial temporal lobeSimple visual stimuliTemporal lobe damageHigher cognitive functionsWhole-brain analysisReorganization of networksMore fundamental processesNeuropsychological modelFMRI taskMTL functionParahippocampal activationTypical adultsAssociative processesMTL structuresBehavioral performanceVisual stimuli