2017
Improving language mapping in clinical fMRI through assessment of grammar
Połczyńska M, Japardi K, Curtiss S, Moody T, Benjamin C, Cho A, Vigil C, Kuhn T, Jones M, Bookheimer S. Improving language mapping in clinical fMRI through assessment of grammar. NeuroImage Clinical 2017, 15: 415-427. PMID: 28616382, PMCID: PMC5458087, DOI: 10.1016/j.nicl.2017.05.021.Peer-Reviewed Original ResearchConceptsPre-operative fMRIIntraoperative cortical stimulationLeft hemisphereGood predictive valueHemisphere language dominanceLanguage-dominant hemisphereFunctional magnetic resonanceSurgical candidatesCortical stimulationFMRI testingBrain tumorsDominant hemisphereClinical fMRIPredictive valueBrain surgeryPatientsLanguage mappingStandard testsFMRI activationFMRI protocolFMRI testsRight hemisphereGrammar testRobust activationGroup levelPresurgical language fMRI: Mapping of six critical regions
Benjamin CF, Walshaw PD, Hale K, Gaillard WD, Baxter LC, Berl MM, Polczynska M, Noble S, Alkawadri R, Hirsch LJ, Constable RT, Bookheimer SY. Presurgical language fMRI: Mapping of six critical regions. Human Brain Mapping 2017, 38: 4239-4255. PMID: 28544168, PMCID: PMC5518223, DOI: 10.1002/hbm.23661.Peer-Reviewed Original ResearchConceptsLanguage lateralityWernicke's areaLanguage regionsBasal temporal language areaHum Brain MappTemporal language areaTumor patientsLanguage cortexIndependent cliniciansClinical fMRIExperienced cliniciansCliniciansLanguage mappingLanguage-critical areasSpeech areasAngular gyrusExner's areaLateralityFMRI taskBroca's areaBlind reviewNeurosurgical planningLanguage areasClinical neuropsychologistsFMRI data
2016
Language system organization in a quadrilingual with a brain tumor: Implications for understanding of the language network
Połczyńska MM, Benjamin CF, Japardi K, Frew A, Bookheimer SY. Language system organization in a quadrilingual with a brain tumor: Implications for understanding of the language network. Neuropsychologia 2016, 86: 167-175. PMID: 27143224, DOI: 10.1016/j.neuropsychologia.2016.04.030.Peer-Reviewed Original ResearchConceptsLanguage mappingPre-operative functional magnetic resonance imagingLanguage-specific regionsFunctional magnetic resonance imagingAge of acquisitionIntraoperative language mappingAmount of exposureMultilingual speakersSecond languageFourth languageMultilingual individualsFrontal brain tumorLanguage similarityLanguage systemNeurocognitive modelsLanguageLanguage networkAge 5Different organizationsSpeakersMagnetic resonance imagingResonance imagingImpairmentSystem organizationOrganization
2014
Elemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy
Benjamin CF, Saling MM, Wood AG, Reutens DC. Elemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy. PLOS ONE 2014, 9: e100891. PMID: 24978828, PMCID: PMC4076213, DOI: 10.1371/journal.pone.0100891.Peer-Reviewed Original ResearchConceptsMTL damageAssociation formationAssociative processingTemporal lobe epilepsyMesial temporal lobe damageNovel fMRI taskCognitive neuropsychological modelGroup whole-brain analysesLeft Temporal Lobe EpilepsyMesial temporal lobeSimple visual stimuliTemporal lobe damageHigher cognitive functionsWhole-brain analysisReorganization of networksMore fundamental processesNeuropsychological modelFMRI taskMTL functionParahippocampal activationTypical adultsAssociative processesMTL structuresBehavioral performanceVisual stimuli
2012
Optimization of tractography of the optic radiations
Benjamin CF, Singh JM, Prabhu SP, Warfield SK. Optimization of tractography of the optic radiations. Human Brain Mapping 2012, 35: 683-697. PMID: 23225566, PMCID: PMC4083652, DOI: 10.1002/hbm.22204.Peer-Reviewed Original Research
2010
Neuropsychological function in patients with a single gene mutation associated with autosomal dominant nocturnal frontal lobe epilepsy
Wood AG, Saling MM, Fedi M, Berkovic SF, Scheffer IE, Benjamin C, Reutens DC. Neuropsychological function in patients with a single gene mutation associated with autosomal dominant nocturnal frontal lobe epilepsy. Epilepsy & Behavior 2010, 17: 531-535. PMID: 20189461, DOI: 10.1016/j.yebeh.2010.01.168.Peer-Reviewed Original ResearchConceptsFrontal lobe functionAutosomal dominant nocturnal frontal lobe epilepsyCognitive flexibilityLobe functionEducation-matched control participantsCore cognitive deficitAspects of memoryFrontal lobe epilepsyVerbal memory impairmentNocturnal frontal lobe epilepsyLevel of impairmentIntellectual abilityNeuropsychological functionNeuropsychological phenotypeCognitive deficitsControl participantsMemory impairmentLobe epilepsyStandard clinical testsFocused measuresGroup of ageImpairmentTaskDisease-related factorsMemory
2005
Increased serotonin receptor availability in human sleep: Evidence from an [18F]MPPF PET study in narcolepsy
Derry C, Benjamin C, Bladin P, le Bars D, Tochon-Danguy H, Berkovic SF, Zimmer L, Costes N, Mulligan R, Reutens D. Increased serotonin receptor availability in human sleep: Evidence from an [18F]MPPF PET study in narcolepsy. NeuroImage 2005, 30: 341-348. PMID: 16275016, DOI: 10.1016/j.neuroimage.2005.09.052.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsBlood PressureBrainCentral Nervous System StimulantsFemaleHumansKineticsMagnetic Resonance ImagingMaleMethylphenidateMiddle AgedNarcolepsyPiperazinesPolysomnographyPositron-Emission TomographyPyridinesRadiopharmaceuticalsRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1AReceptors, SerotoninSerotoninSleepConceptsSerotonin receptor availabilityReceptor availabilityMethylphenidate administrationSuppress REM sleepSprague-Dawley ratsPositron emission tomographyNarcoleptic humansNormal medicationEndogenous serotoninSerotonergic neurotransmissionREM sleepStimulant methylphenidatePET scansAnimal studiesHuman studiesWhole brainEmission tomographySleep scanPET studiesSleepWakefulnessHuman sleepScansT-testSignificant increase