Increased serotonin receptor availability in human sleep: Evidence from an [18F]MPPF PET study in narcolepsy
Derry C, Benjamin C, Bladin P, le Bars D, Tochon-Danguy H, Berkovic SF, Zimmer L, Costes N, Mulligan R, Reutens D. Increased serotonin receptor availability in human sleep: Evidence from an [18F]MPPF PET study in narcolepsy. NeuroImage 2005, 30: 341-348. PMID: 16275016, DOI: 10.1016/j.neuroimage.2005.09.052.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsBlood PressureBrainCentral Nervous System StimulantsFemaleHumansKineticsMagnetic Resonance ImagingMaleMethylphenidateMiddle AgedNarcolepsyPiperazinesPolysomnographyPositron-Emission TomographyPyridinesRadiopharmaceuticalsRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1AReceptors, SerotoninSerotoninSleepConceptsSerotonin receptor availabilityReceptor availabilityMethylphenidate administrationSuppress REM sleepSprague-Dawley ratsPositron emission tomographyNarcoleptic humansNormal medicationEndogenous serotoninSerotonergic neurotransmissionREM sleepStimulant methylphenidatePET scansAnimal studiesHuman studiesWhole brainEmission tomographySleep scanPET studiesSleepWakefulnessHuman sleepScansT-testSignificant increase