2010
Neuropsychological function in patients with a single gene mutation associated with autosomal dominant nocturnal frontal lobe epilepsy
Wood AG, Saling MM, Fedi M, Berkovic SF, Scheffer IE, Benjamin C, Reutens DC. Neuropsychological function in patients with a single gene mutation associated with autosomal dominant nocturnal frontal lobe epilepsy. Epilepsy & Behavior 2010, 17: 531-535. PMID: 20189461, DOI: 10.1016/j.yebeh.2010.01.168.Peer-Reviewed Original ResearchConceptsFrontal lobe functionAutosomal dominant nocturnal frontal lobe epilepsyCognitive flexibilityLobe functionEducation-matched control participantsCore cognitive deficitAspects of memoryFrontal lobe epilepsyVerbal memory impairmentNocturnal frontal lobe epilepsyLevel of impairmentIntellectual abilityNeuropsychological functionNeuropsychological phenotypeCognitive deficitsControl participantsMemory impairmentLobe epilepsyStandard clinical testsFocused measuresGroup of ageImpairmentTaskDisease-related factorsMemory
2005
Increased serotonin receptor availability in human sleep: Evidence from an [18F]MPPF PET study in narcolepsy
Derry C, Benjamin C, Bladin P, le Bars D, Tochon-Danguy H, Berkovic SF, Zimmer L, Costes N, Mulligan R, Reutens D. Increased serotonin receptor availability in human sleep: Evidence from an [18F]MPPF PET study in narcolepsy. NeuroImage 2005, 30: 341-348. PMID: 16275016, DOI: 10.1016/j.neuroimage.2005.09.052.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsBlood PressureBrainCentral Nervous System StimulantsFemaleHumansKineticsMagnetic Resonance ImagingMaleMethylphenidateMiddle AgedNarcolepsyPiperazinesPolysomnographyPositron-Emission TomographyPyridinesRadiopharmaceuticalsRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1AReceptors, SerotoninSerotoninSleepConceptsSerotonin receptor availabilityReceptor availabilityMethylphenidate administrationSuppress REM sleepSprague-Dawley ratsPositron emission tomographyNarcoleptic humansNormal medicationEndogenous serotoninSerotonergic neurotransmissionREM sleepStimulant methylphenidatePET scansAnimal studiesHuman studiesWhole brainEmission tomographySleep scanPET studiesSleepWakefulnessHuman sleepScansT-testSignificant increase