2019
Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis
Won C, Reid M, Sofer T, Azarbarzin A, Purcell S, White D, Wellman A, Sands S, Redline S. Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis. Sleep 2019, 43: zsz274. PMID: 31687772, PMCID: PMC7215264, DOI: 10.1093/sleep/zsz274.Peer-Reviewed Original ResearchMeSH KeywordsAtherosclerosisFemaleHumansMalePhenotypeRetrospective StudiesSex CharacteristicsSleep Apnea, ObstructiveSleep, REMConceptsApnea-hypopnea indexObstructive sleep apneaMulti-Ethnic StudyArousal criteriaObstructive sleep apnea phenotypesSex differencesLow arousal thresholdRelative sex differencesApnea phenotypesNREM-AHIPathophysiological endotypesREM-OSAAirway collapsibilityOSA prevalenceSleep apneaDesaturation criteriaEndotypesSex disparitiesArousal thresholdPolysomnography dataSignificant sex differencesREM eventsWomenLow loop gainNREM
2015
Gender differences in sleep disordered breathing: implications for therapy
Won C, Guilleminault C. Gender differences in sleep disordered breathing: implications for therapy. Expert Review Of Respiratory Medicine 2015, 9: 221-231. PMID: 25739831, DOI: 10.1586/17476348.2015.1019478.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep-disordered breathingSeverity of OSAUpper airway functionGender-related differencesAirway functionEndothelial dysfunctionLung functionComorbid conditionsSleep apneaTreatment optionsRespiratory stabilityImproved outcomesGender differencesGreater riskAdverse effectsWomenLimited dataAge increasesBreathingFemale presentationsHypertensionApneaAirwayPregnancy