2022
Risk Assessment in the Molecular Era
Knowlton CA, Jimenez RB, Moran MS. Risk Assessment in the Molecular Era. Seminars In Radiation Oncology 2022, 32: 189-197. PMID: 35688517, DOI: 10.1016/j.semradonc.2022.01.005.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingFemaleHumansMastectomy, SegmentalNeoplasm Recurrence, LocalRisk AssessmentConceptsBreast-conserving surgeryClinical-pathologic featuresHormone receptor-positive diseaseLow-risk DCIS patientsLow-risk DCISAdjuvant endocrine therapyLocal control rateMajority of patientsSpecific survival outcomesPersonalized risk assessmentMolecular assaysBreast recurrenceDCIS patientsDCIS ScoreRT recommendationsDefinitive surgeryEndocrine therapyPostoperative radiotherapyPositive diseaseDuctal carcinomaSurvival outcomesControl rateInvasive cancerTreatment paradigmBreast cancer
2019
Patient-Reported Outcomes and Cosmesis in a Feasibility Study of 4-Dimensional Simulated Image Guided Accelerated Partial Breast Irradiation
Rahimy E, Weidhaas J, Wei W, Lannin D, Horowitz N, Higgins S, Wilson LD, Knowlton C, Moran MS, Young MR, Killelea B, Chagpar A, Yeboa DN, Zelterman D, Evans S. Patient-Reported Outcomes and Cosmesis in a Feasibility Study of 4-Dimensional Simulated Image Guided Accelerated Partial Breast Irradiation. Practical Radiation Oncology 2019, 9: e257-e265. PMID: 30796975, DOI: 10.1016/j.prro.2019.01.013.Peer-Reviewed Original ResearchConceptsPartial breast irradiationDosimetric constraintsBreast irradiationCosmetic outcomePoor cosmesisToxicity gradeBreast cancerKarnofsky performance status scoreTarget volumeAccelerated Partial Breast IrradiationSmaller planning target volumesAcceptable cosmetic outcomeAdverse cosmetic outcomePathologic tumor sizePerformance status scoreI breast cancerBreast-conserving surgeryThree-dimensional conformalDose-volume relationshipPlanning target volumeComputed tomography simulationDaily image guidanceLocoregional recurrencePrimary endpointTumor size