Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report
Jacobsen L, Giedd J, Kreek M, Gottschalk C, Kosten T. Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report. Drug And Alcohol Dependence 2001, 62: 49-56. PMID: 11173167, DOI: 10.1016/s0376-8716(00)00159-9.Peer-Reviewed Original ResearchConceptsTotal brain volumeAdrenocorticotropin hormoneMagnetic resonance imagingCocaine dependenceHealthy subjectsHippocampal damageBrain volumeCortisol levelsAdrenal axis functionChronic cocaine dependenceCocaine-dependent subjectsCocaine-dependent patientsDays of abstinenceDirect toxic effectMedial temporal lobeAxis functionChronic elevationDependent patientsClinical studiesHippocampal neuronsTemporal lobeOvine corticotropinPlasma cortisolResonance imagingDependent subjectsFunctional Magnetic Resonance Imaging of Cocaine Craving
Wexler BE, Gottschalk CH, Fulbright RK, Prohovnik I, Lacadie CM, Rounsaville BJ, Gore JC. Functional Magnetic Resonance Imaging of Cocaine Craving. American Journal Of Psychiatry 2001, 158: 86-95. PMID: 11136638, DOI: 10.1176/appi.ajp.158.1.86.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingHealthy subjectsCocaine-dependent subjectsMagnetic resonance imagingResonance imagingCocaine addictsReported onsetBrain activationBrain activityRegional brain activationFrontal lobe activationAnterior cingulate activationNeurobiology of addictionCocaine cravingAnterior cingulatePatientsFrontal lobePhysiologic linkSensory areasComparison of groupsDrug cravingDysphoric statesLess activationGeneral abnormalityCingulate activation