2024
Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice
Thomas J, Schindler E, Gottschalk C. Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice. Journal Of Clinical Investigation 2024, 134: e182556. PMID: 39087472, PMCID: PMC11290958, DOI: 10.1172/jci182556.Peer-Reviewed Original ResearchConceptsBlocking CGRP signalingCGRP receptor componentsMigraine-like painCervical lymph nodesGap junction proteinPrimary headache disordersLymphatic vessel dysfunctionAcute migrainePharmacological blockadeLymph nodesHeadache disordersNeurological symptomsJunction proteinsCGRPLymphatic vesselsMeningeal lymphatic vesselsInducible knockoutVessel dysfunctionMigraineReceptor componentsHeadachePainPathophysiologyDysfunctionMice
2022
The Epidemiology of Primary Headache Disorders
Kopel D, Gottschalk C. The Epidemiology of Primary Headache Disorders. Seminars In Neurology 2022, 42: 449-458. PMID: 36104164, DOI: 10.1055/a-1942-6823.Peer-Reviewed Original ResearchConceptsPrimary headache disordersHeadache disordersCommon primary headache disorderHigher migraine prevalenceNumber 1 causeCommon headache disorderCause of disabilityBurden of migrainePopulation-based estimatesTension-type headacheAmerican Indian/Alaskan NativeAI/AN menChronic migrainePrevalence of stigmaMigraine prevalenceGlobal burdenClinical careEpidemiologic studiesMigraine incidenceMigrainePrevalence estimatesDisease StudyPrevalenceAlaskan NativesDisorders