Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report
Jacobsen L, Giedd J, Kreek M, Gottschalk C, Kosten T. Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report. Drug And Alcohol Dependence 2001, 62: 49-56. PMID: 11173167, DOI: 10.1016/s0376-8716(00)00159-9.Peer-Reviewed Original ResearchConceptsTotal brain volumeAdrenocorticotropin hormoneMagnetic resonance imagingCocaine dependenceHealthy subjectsHippocampal damageBrain volumeCortisol levelsAdrenal axis functionChronic cocaine dependenceCocaine-dependent subjectsCocaine-dependent patientsDays of abstinenceDirect toxic effectMedial temporal lobeAxis functionChronic elevationDependent patientsClinical studiesHippocampal neuronsTemporal lobeOvine corticotropinPlasma cortisolResonance imagingDependent subjects