2024
Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina
Estay S, Morales-Moraga C, Vielma A, Palacios-Muñoz A, Chiu C, Chávez A. Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina. IScience 2024, 27: 109920. PMID: 38799553, PMCID: PMC11126983, DOI: 10.1016/j.isci.2024.109920.Peer-Reviewed Original ResearchA17 amacrine cellsRod bipolar cellsVisual processingType 1 cannabinoid receptorGABAergic feedback inhibitionNon-canonical mechanismRat retinal slicesAmacrine cellsCB1R activationRetinal slicesGlutamate releaseInner retinaRat retinaRetinal neuronsRod pathwayCB1RExchange proteinFeedback inhibitionBipolar cellsRod-drivenAxon terminalsTime courseGABAVisual responsesRetina
2023
Microbiota and Diapause-Induced Neuroprotection Share a Dependency on Calcium But Differ in Their Effects on Mitochondrial Morphology
Delgado S, Urrutia A, Gutzwiller F, Chiu C, Calixto A. Microbiota and Diapause-Induced Neuroprotection Share a Dependency on Calcium But Differ in Their Effects on Mitochondrial Morphology. ENeuro 2023, 10: eneuro.0424-22.2023. PMID: 37385728, PMCID: PMC10368204, DOI: 10.1523/eneuro.0424-22.2023.Peer-Reviewed Original ResearchConceptsCaenorhabditis elegans</i>Length of mitochondriaDiapause entryLactate-producing bacteriaReverse geneticsGut microbiotaMitochondrial morphologyTranscriptomic approachMitochondrial sizeMitochondrial functionMicrobiotaMechanistic commonalitiesEnvironmental variablesBacteriaMCU-1GenesNeuronal functionMultiple mechanismsCalcium homeostasisDiapauseNeuronal degenerationNeuronal protectionRegeneration of damaged neuronsFood deprivationTranscriptome
2022
Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease
Meza R, Ancatén-González C, Chiu C, Chávez A. Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease. Frontiers In Cellular Neuroscience 2022, 16: 864828. PMID: 35518644, PMCID: PMC9062234, DOI: 10.3389/fncel.2022.864828.Peer-Reviewed Original ResearchTransient receptor potential vanilloid 1Synaptic plasticityTRPV1 functionActivity-dependent synaptic changesLigand-gated nonselective cation channelCentral synapsesNonselective cation channelsRegulate synaptic functionVanilloid 1Pain sensationCation channelsHealth and DiseaseSynaptic efficacySynaptic changesBrain regionsPostsynaptic compartmentsNeurotransmitter releasePresynaptic terminalsTherapeutic treatmentSynaptic functionBrain disordersPotential roleSynapsesBrainPainLong-Range GABAergic Projections of Cortical Origin in Brain Function
Urrutia-Piñones J, Morales-Moraga C, Sanguinetti-González N, Escobar A, Chiu C. Long-Range GABAergic Projections of Cortical Origin in Brain Function. Frontiers In Systems Neuroscience 2022, 16: 841869. PMID: 35392440, PMCID: PMC8981584, DOI: 10.3389/fnsys.2022.841869.Peer-Reviewed Original Research
2020
Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus
Fuenzalida M, Chiu C, Chávez A. Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus. Neuroscience 2020, 456: 50-59. PMID: 32828940, DOI: 10.1016/j.neuroscience.2020.08.015.Peer-Reviewed Original ResearchConceptsSpike timing dependent synaptic plasticityTiming-dependent plasticityCellular basis of learningMagnitude of long-term changesMuscarinic receptorsInhibitory synapsesMuscarinic regulationSynaptic transmissionSynaptic plasticityShape learningCentral synapsesBasis of learningCellular basisNetwork activityBrain network activityLong-term changesAcetylcholineHippocampusLearningSynapsesSTDPBrainMuscarinicMemoryReceptors
2019
Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity
Chiu CQ, Barberis A, Higley MJ. Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity. Nature Reviews Neuroscience 2019, 20: 272-281. PMID: 30837689, DOI: 10.1038/s41583-019-0141-5.Peer-Reviewed Original ResearchConceptsGABAergic synaptic plasticityInhibitory GABAergic synapsesPostsynaptic action potentialsInhibitory synaptic strengthGABAergic synapsesSynaptic excitationLong-term plasticityGlutamatergic signalingNeuronal activitySynaptic plasticityNeuronal circuitsAction potentialsSynaptic strengthIndividual neuronsCellular mechanismsLines of evidenceBody of literaturePlasticityNeuronsFunctional stabilitySynapses
2018
Input-Specific NMDAR-Dependent Potentiation of Dendritic GABAergic Inhibition
Chiu CQ, Martenson JS, Yamazaki M, Natsume R, Sakimura K, Tomita S, Tavalin SJ, Higley MJ. Input-Specific NMDAR-Dependent Potentiation of Dendritic GABAergic Inhibition. Neuron 2018, 97: 368-377.e3. PMID: 29346754, PMCID: PMC5777295, DOI: 10.1016/j.neuron.2017.12.032.Peer-Reviewed Original ResearchConceptsDendritic inhibitionInput-specific long-term potentiationNMDA-type glutamate receptorsGABAergic inhibitory synapsesSomatostatin-expressing interneuronsGABA-A receptorsNormal brain functionLong-term potentiationForms of plasticityHomeostatic cellular mechanismsGABAergic inhibitionSynaptic excitationPerisomatic inhibitionPostsynaptic spikingInhibitory synapsesLong-term plasticityGlutamate receptorsInhibitory inputsSynaptic transmissionDependent potentiationCortical circuitsGenetic deletionBrain functionNeuronal dendritesCellular mechanisms
2013
Wavelength-Selective One- and Two-Photon Uncaging of GABA
Amatrudo JM, Olson JP, Lur G, Chiu CQ, Higley MJ, Ellis-Davies GC. Wavelength-Selective One- and Two-Photon Uncaging of GABA. ACS Chemical Neuroscience 2013, 5: 64-70. PMID: 24304264, PMCID: PMC3894722, DOI: 10.1021/cn400185r.Peer-Reviewed Original ResearchCompartmentalization of GABAergic Inhibition by Dendritic Spines
Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Compartmentalization of GABAergic Inhibition by Dendritic Spines. Science 2013, 340: 759-762. PMID: 23661763, PMCID: PMC3752161, DOI: 10.1126/science.1234274.Peer-Reviewed Original ResearchConceptsGABAergic inhibitionDendritic spinesPerisomatic inhibitory synapsesPyramidal cell dendritesTwo-photon calcium imagingAction potential outputAcid-mediated inhibitionIndividual dendritic spinesGABAergic controlGABAergic synapsesPyramidal neuronsCell dendritesInhibitory synapsesNeuronal activityCalcium imagingSpine headsInhibitory actionNeocortexInhibitionSpineSynapsesCompartmentalized controlCritical roleSignalingPostsynapticOptically Selective Two-Photon Uncaging of Glutamate at 900 nm
Olson JP, Kwon HB, Takasaki KT, Chiu CQ, Higley MJ, Sabatini BL, Ellis-Davies GC. Optically Selective Two-Photon Uncaging of Glutamate at 900 nm. Journal Of The American Chemical Society 2013, 135: 5954-5957. PMID: 23577752, PMCID: PMC4079120, DOI: 10.1021/ja4019379.Peer-Reviewed Original ResearchConceptsTwo-photon excitation
2011
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
Tsetsenis T, Younts T, Chiu C, Kaeser P, Castillo P, Südhof T. Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 14300-14305. PMID: 21844341, PMCID: PMC3161598, DOI: 10.1073/pnas.1112237108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCA1 Region, HippocampalExcitatory Postsynaptic PotentialsExtinction, PsychologicalFearGene DeletionHippocampusInhibitory Postsynaptic PotentialsLong-Term Synaptic DepressionMiceMice, KnockoutModels, NeurologicalRab3 GTP-Binding ProteinsReversal LearningSynapsesSynaptic TransmissionConceptsLong-term potentiationI-LTDLong-term depressionInhibitory synapsesRab3-interacting moleculeEndocannabinoid-dependent long-term depressionLong-term plasticityRab3 isoformsKO miceMorris water-mazeFear conditioning assaysPresynaptically expressed long-term potentiationNMDA receptor-dependent long-term potentiationInitial phase of learningHippocampal inhibitory synapsesPhases of learningReversal learningWater-mazeGTP-dependent mannerSynaptic vesicle proteinsAcute slicesCA1 regionPresynaptic formShort-term plasticityExcitatory synapsesLong-term plasticity at inhibitory synapses
Castillo P, Chiu C, Carroll R. Long-term plasticity at inhibitory synapses. Current Opinion In Neurobiology 2011, 21: 328-338. PMID: 21334194, PMCID: PMC3092861, DOI: 10.1016/j.conb.2011.01.006.Peer-Reviewed Original ResearchConceptsSynaptic plasticityInhibitory synaptic plasticityModification of neural circuitsNeural circuitsNeural circuit refinementNeural circuit functionGABAergic plasticityRegulate excitabilityExcitatory/inhibitory balanceInhibitory plasticityCircuit refinementExcitatory synapsesLong-term plasticitySynaptic efficacyFunctional relevanceCircuit functionDiverse mechanismsLTP/LTDEfficacySynapses
2010
TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus
Chávez A, Chiu C, Castillo P. TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus. Nature Neuroscience 2010, 13: 1511-1518. PMID: 21076423, PMCID: PMC3058928, DOI: 10.1038/nn.2684.Peer-Reviewed Original ResearchConceptsDentate gyrusLong-term depressionInternalization of AMPA receptorsActivation of TRPV-1Postsynaptic long-term depressionExcitatory synaptic transmissionEndocannabinoid receptorsAMPA receptorsTRPV-1TRPV1 activationGyrusSynaptic transmissionDentateClathrin-dependent internalizationReceptorsEndocannabinoidAnandamideDepressionTRPV1Endocannabinoid Mediated Long-Term Depression at Inhibitory Synapses
Chiu C, Castillo P. Endocannabinoid Mediated Long-Term Depression at Inhibitory Synapses. 2010, 149-166. DOI: 10.1007/978-1-4419-6978-1_11.Peer-Reviewed Original ResearchI-LTDLong-term potentiationSynaptic plasticityActivating presynaptic type 1 cannabinoid receptorsHeterosynaptic form of plasticityType 1 cannabinoid receptorInhibitory synapsesGABAergic synaptic plasticityMetabotropic glutamatergic receptorsExcitatory synaptic plasticityBasis of learningECB mobilizationFunction of neural circuitsCellular basis of learningBrain structuresExcitability of neuronsExcitatory glutamatergic synapsesGlutamatergic receptorsExcitatory/inhibitory balanceGABA releaseRetrograde messengerActivity-dependent changesNeural circuitsGABAergic synapsesGlutamatergic synapsesDopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex
Chiu C, Puente N, Grandes P, Castillo P. Dopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex. Journal Of Neuroscience 2010, 30: 7236-7248. PMID: 20505090, PMCID: PMC2905527, DOI: 10.1523/jneurosci.0736-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBenzoxazinesCannabinoid Receptor ModulatorsChelating AgentsDopamineDopamine AgentsEgtazic AcidEndocannabinoidsFemaleGamma-Aminobutyric AcidIn Vitro TechniquesInhibitory Postsynaptic PotentialsIsoquinolinesMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionMorpholinesNaphthalenesNeuronal PlasticityPatch-Clamp TechniquesPiperidinesPrefrontal CortexProtein Kinase InhibitorsPyrazolesRatsRats, WistarReceptor, Cannabinoid, CB1Receptors, Dopamine D2Silver StainingSulfonamidesSynapsesConceptsPrefrontal cortexI-LTDECB-mediated long-term depressionLong-term depression of inhibitory transmissionPrefrontal cortex of ratsDopamine type 2 receptorPrefrontal cortical functionEndocannabinoid-mediated plasticityEndogenous cannabinoid receptorsGroup I metabotropic glutamate receptorsCannabinoid receptor systemSuppress GABA releaseECB signalingECB-LTDWorking memoryDopaminergic modulationCannabinoid receptorsBrain regionsGABA releaseDopamineEmotional learningCortical functionInhibitory transmissionGABAergic synapsesElectrophysiological evidence
2008
RIM1α and RIM1β Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions
Kaeser P, Kwon H, Chiu C, Deng L, Castillo P, Südhof T. RIM1α and RIM1β Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions. Journal Of Neuroscience 2008, 28: 13435-13447. PMID: 19074017, PMCID: PMC2701653, DOI: 10.1523/jneurosci.3235-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsExcitatory Postsynaptic PotentialsGTP-Binding ProteinsHippocampusMiceMice, KnockoutNeuronal PlasticityNeurotransmitter AgentsOrgan Culture TechniquesPatch-Clamp TechniquesPresynaptic TerminalsPromoter Regions, GeneticProtein IsoformsReverse Transcriptase Polymerase Chain ReactionSynapsesSynaptic TransmissionSynaptic VesiclesConceptsRIM1 geneActive zone proteinsKnock-out miceSynaptic vesicle primingPresynaptic long-term plasticitySynaptic vesicle proteinsNeurotransmitter releaseLong-term presynaptic plasticityVesicle primingActive zoneMultidomain proteinsSynaptotagmin-1Vesicle proteinsRIM1alphaN-terminusRIM1Plasma membranePresynaptic plasticityDeletionGenesSynaptic functionPresynaptic terminalsProteinIsoformsShort-term synaptic plasticity
2007
Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus
Chiu C, Castillo P. Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology 2007, 54: 68-78. PMID: 17706254, PMCID: PMC2225485, DOI: 10.1016/j.neuropharm.2007.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornArachidonic AcidsBenzoxazinesCalciumCalcium Channel BlockersCannabinoid Receptor ModulatorsCholinergic AgentsDentate GyrusElectric StimulationEndocannabinoidsExcitatory Postsynaptic PotentialsGlyceridesIn Vitro TechniquesMiceMice, Inbred C57BLMice, KnockoutMorpholinesNaphthalenesNeural PathwaysNeuronal PlasticityNeuronsPatch-Clamp TechniquesRatsRats, WistarReceptor, Cannabinoid, CB1ConceptsECB signalingDentate gyrusDiacyglycerol lipaseGroup I metabotropic glutamate receptorsDepress excitatory synaptic transmissionSuppression of excitationBreakdown of anandamideExcitatory synapsesMedial perforant pathAbundant eCBECB-LTDECB releaseCannabinoid receptorsExcitatory synaptic transmissionBrain structuresGlutamatergic inputsEntorhinal cortexSynaptic plasticityGlutamate receptorsPerforant pathDentate granule cellsDentateEndocannabinoidGyrusAnandamide
2004
Small modulation of ongoing cortical dynamics by sensory input during natural vision
Fiser J, Chiu C, Weliky M. Small modulation of ongoing cortical dynamics by sensory input during natural vision. Nature 2004, 431: 573-578. PMID: 15457262, DOI: 10.1038/nature02907.Peer-Reviewed Original ResearchConceptsDynamics of spontaneous activitySpontaneous activityVisual cortexPrimary visual cortexRandom spontaneous activitySpontaneous neural firingVisual cortical neuronsMature visual cortexCortical dynamicsNeural activityEvoked neural activitySensory inputInput signalCortical neuronsCircuit dynamicsNeural firingVisual stimulationMature animalsDynamicsYoung animalsFilm imagesCortexNeural responsesNatural visionNatural viewing conditionsMulti-electrode recording from the developing visual pathway of awake behaving ferrets
Chiu C, Weliky M. Multi-electrode recording from the developing visual pathway of awake behaving ferrets. Journal Of Neuroscience Methods 2004, 136: 55-61. PMID: 15126045, DOI: 10.1016/j.jneumeth.2003.12.017.Peer-Reviewed Original Research
2003
The Role of Neural Activity in the Development of Orientation Selectivity
Chiu C, Weliky M. The Role of Neural Activity in the Development of Orientation Selectivity. 2003, 117-125. DOI: 10.7551/mitpress/7131.003.0013.Peer-Reviewed Original ResearchVisual neuroscienceComputer scienceMassive collectionObject recognitionNetwork modelComputational perspectiveDevelopment of orientation selectivityOrganization of visual pathwaysSubcortical processingVisual sciencePrimary visual cortexNeural activityVision scienceOrientation selectivityCognitive scienceEye movementsNeuroscienceVisual cortexSpatial relationshipsVisual pathwayNeuralNetworkComputerCognitionPsychology