2018
Input-Specific NMDAR-Dependent Potentiation of Dendritic GABAergic Inhibition
Chiu CQ, Martenson JS, Yamazaki M, Natsume R, Sakimura K, Tomita S, Tavalin SJ, Higley MJ. Input-Specific NMDAR-Dependent Potentiation of Dendritic GABAergic Inhibition. Neuron 2018, 97: 368-377.e3. PMID: 29346754, PMCID: PMC5777295, DOI: 10.1016/j.neuron.2017.12.032.Peer-Reviewed Original ResearchConceptsDendritic inhibitionInput-specific long-term potentiationNMDA-type glutamate receptorsGABAergic inhibitory synapsesSomatostatin-expressing interneuronsGABA-A receptorsNormal brain functionLong-term potentiationForms of plasticityHomeostatic cellular mechanismsGABAergic inhibitionSynaptic excitationPerisomatic inhibitionPostsynaptic spikingInhibitory synapsesLong-term plasticityGlutamate receptorsInhibitory inputsSynaptic transmissionDependent potentiationCortical circuitsGenetic deletionBrain functionNeuronal dendritesCellular mechanisms
2013
Wavelength-Selective One- and Two-Photon Uncaging of GABA
Amatrudo JM, Olson JP, Lur G, Chiu CQ, Higley MJ, Ellis-Davies GC. Wavelength-Selective One- and Two-Photon Uncaging of GABA. ACS Chemical Neuroscience 2013, 5: 64-70. PMID: 24304264, PMCID: PMC3894722, DOI: 10.1021/cn400185r.Peer-Reviewed Original ResearchCompartmentalization of GABAergic Inhibition by Dendritic Spines
Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Compartmentalization of GABAergic Inhibition by Dendritic Spines. Science 2013, 340: 759-762. PMID: 23661763, PMCID: PMC3752161, DOI: 10.1126/science.1234274.Peer-Reviewed Original ResearchConceptsGABAergic inhibitionDendritic spinesPerisomatic inhibitory synapsesPyramidal cell dendritesTwo-photon calcium imagingAction potential outputAcid-mediated inhibitionIndividual dendritic spinesGABAergic controlGABAergic synapsesPyramidal neuronsCell dendritesInhibitory synapsesNeuronal activityCalcium imagingSpine headsInhibitory actionNeocortexInhibitionSpineSynapsesCompartmentalized controlCritical roleSignalingPostsynaptic
2010
Dopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex
Chiu C, Puente N, Grandes P, Castillo P. Dopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex. Journal Of Neuroscience 2010, 30: 7236-7248. PMID: 20505090, PMCID: PMC2905527, DOI: 10.1523/jneurosci.0736-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBenzoxazinesCannabinoid Receptor ModulatorsChelating AgentsDopamineDopamine AgentsEgtazic AcidEndocannabinoidsFemaleGamma-Aminobutyric AcidIn Vitro TechniquesInhibitory Postsynaptic PotentialsIsoquinolinesMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionMorpholinesNaphthalenesNeuronal PlasticityPatch-Clamp TechniquesPiperidinesPrefrontal CortexProtein Kinase InhibitorsPyrazolesRatsRats, WistarReceptor, Cannabinoid, CB1Receptors, Dopamine D2Silver StainingSulfonamidesSynapsesConceptsPrefrontal cortexI-LTDECB-mediated long-term depressionLong-term depression of inhibitory transmissionPrefrontal cortex of ratsDopamine type 2 receptorPrefrontal cortical functionEndocannabinoid-mediated plasticityEndogenous cannabinoid receptorsGroup I metabotropic glutamate receptorsCannabinoid receptor systemSuppress GABA releaseECB signalingECB-LTDWorking memoryDopaminergic modulationCannabinoid receptorsBrain regionsGABA releaseDopamineEmotional learningCortical functionInhibitory transmissionGABAergic synapsesElectrophysiological evidence