2023
Microbiota and Diapause-Induced Neuroprotection Share a Dependency on Calcium But Differ in Their Effects on Mitochondrial Morphology
Delgado S, Urrutia A, Gutzwiller F, Chiu C, Calixto A. Microbiota and Diapause-Induced Neuroprotection Share a Dependency on Calcium But Differ in Their Effects on Mitochondrial Morphology. ENeuro 2023, 10: eneuro.0424-22.2023. PMID: 37385728, PMCID: PMC10368204, DOI: 10.1523/eneuro.0424-22.2023.Peer-Reviewed Original ResearchConceptsCaenorhabditis elegans</i>Length of mitochondriaDiapause entryLactate-producing bacteriaReverse geneticsGut microbiotaMitochondrial morphologyTranscriptomic approachMitochondrial sizeMitochondrial functionMicrobiotaMechanistic commonalitiesEnvironmental variablesBacteriaMCU-1GenesNeuronal functionMultiple mechanismsCalcium homeostasisDiapauseNeuronal degenerationNeuronal protectionRegeneration of damaged neuronsFood deprivationTranscriptome
2013
Compartmentalization of GABAergic Inhibition by Dendritic Spines
Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Compartmentalization of GABAergic Inhibition by Dendritic Spines. Science 2013, 340: 759-762. PMID: 23661763, PMCID: PMC3752161, DOI: 10.1126/science.1234274.Peer-Reviewed Original ResearchConceptsGABAergic inhibitionDendritic spinesPerisomatic inhibitory synapsesPyramidal cell dendritesTwo-photon calcium imagingAction potential outputAcid-mediated inhibitionIndividual dendritic spinesGABAergic controlGABAergic synapsesPyramidal neuronsCell dendritesInhibitory synapsesNeuronal activityCalcium imagingSpine headsInhibitory actionNeocortexInhibitionSpineSynapsesCompartmentalized controlCritical roleSignalingPostsynaptic
2007
Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus
Chiu C, Castillo P. Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology 2007, 54: 68-78. PMID: 17706254, PMCID: PMC2225485, DOI: 10.1016/j.neuropharm.2007.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornArachidonic AcidsBenzoxazinesCalciumCalcium Channel BlockersCannabinoid Receptor ModulatorsCholinergic AgentsDentate GyrusElectric StimulationEndocannabinoidsExcitatory Postsynaptic PotentialsGlyceridesIn Vitro TechniquesMiceMice, Inbred C57BLMice, KnockoutMorpholinesNaphthalenesNeural PathwaysNeuronal PlasticityNeuronsPatch-Clamp TechniquesRatsRats, WistarReceptor, Cannabinoid, CB1ConceptsECB signalingDentate gyrusDiacyglycerol lipaseGroup I metabotropic glutamate receptorsDepress excitatory synaptic transmissionSuppression of excitationBreakdown of anandamideExcitatory synapsesMedial perforant pathAbundant eCBECB-LTDECB releaseCannabinoid receptorsExcitatory synaptic transmissionBrain structuresGlutamatergic inputsEntorhinal cortexSynaptic plasticityGlutamate receptorsPerforant pathDentate granule cellsDentateEndocannabinoidGyrusAnandamide