2020
Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus
Fuenzalida M, Chiu C, Chávez A. Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus. Neuroscience 2020, 456: 50-59. PMID: 32828940, DOI: 10.1016/j.neuroscience.2020.08.015.Peer-Reviewed Original ResearchConceptsSpike timing dependent synaptic plasticityTiming-dependent plasticityCellular basis of learningMagnitude of long-term changesMuscarinic receptorsInhibitory synapsesMuscarinic regulationSynaptic transmissionSynaptic plasticityShape learningCentral synapsesBasis of learningCellular basisNetwork activityBrain network activityLong-term changesAcetylcholineHippocampusLearningSynapsesSTDPBrainMuscarinicMemoryReceptors
2019
Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity
Chiu CQ, Barberis A, Higley MJ. Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity. Nature Reviews Neuroscience 2019, 20: 272-281. PMID: 30837689, DOI: 10.1038/s41583-019-0141-5.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBrainGABAergic NeuronsNeural InhibitionNeuronal PlasticitySynapsesConceptsGABAergic synaptic plasticityInhibitory GABAergic synapsesPostsynaptic action potentialsInhibitory synaptic strengthGABAergic synapsesSynaptic excitationLong-term plasticityGlutamatergic signalingNeuronal activitySynaptic plasticityNeuronal circuitsAction potentialsSynaptic strengthIndividual neuronsCellular mechanismsLines of evidenceBody of literaturePlasticityNeuronsFunctional stabilitySynapses
2013
Wavelength-Selective One- and Two-Photon Uncaging of GABA
Amatrudo JM, Olson JP, Lur G, Chiu CQ, Higley MJ, Ellis-Davies GC. Wavelength-Selective One- and Two-Photon Uncaging of GABA. ACS Chemical Neuroscience 2013, 5: 64-70. PMID: 24304264, PMCID: PMC3894722, DOI: 10.1021/cn400185r.Peer-Reviewed Original ResearchCompartmentalization of GABAergic Inhibition by Dendritic Spines
Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Compartmentalization of GABAergic Inhibition by Dendritic Spines. Science 2013, 340: 759-762. PMID: 23661763, PMCID: PMC3752161, DOI: 10.1126/science.1234274.Peer-Reviewed Original ResearchConceptsGABAergic inhibitionDendritic spinesPerisomatic inhibitory synapsesPyramidal cell dendritesTwo-photon calcium imagingAction potential outputAcid-mediated inhibitionIndividual dendritic spinesGABAergic controlGABAergic synapsesPyramidal neuronsCell dendritesInhibitory synapsesNeuronal activityCalcium imagingSpine headsInhibitory actionNeocortexInhibitionSpineSynapsesCompartmentalized controlCritical roleSignalingPostsynaptic
2011
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
Tsetsenis T, Younts T, Chiu C, Kaeser P, Castillo P, Südhof T. Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 14300-14305. PMID: 21844341, PMCID: PMC3161598, DOI: 10.1073/pnas.1112237108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCA1 Region, HippocampalExcitatory Postsynaptic PotentialsExtinction, PsychologicalFearGene DeletionHippocampusInhibitory Postsynaptic PotentialsLong-Term Synaptic DepressionMiceMice, KnockoutModels, NeurologicalRab3 GTP-Binding ProteinsReversal LearningSynapsesSynaptic TransmissionConceptsLong-term potentiationI-LTDLong-term depressionInhibitory synapsesRab3-interacting moleculeEndocannabinoid-dependent long-term depressionLong-term plasticityRab3 isoformsKO miceMorris water-mazeFear conditioning assaysPresynaptically expressed long-term potentiationNMDA receptor-dependent long-term potentiationInitial phase of learningHippocampal inhibitory synapsesPhases of learningReversal learningWater-mazeGTP-dependent mannerSynaptic vesicle proteinsAcute slicesCA1 regionPresynaptic formShort-term plasticityExcitatory synapsesLong-term plasticity at inhibitory synapses
Castillo P, Chiu C, Carroll R. Long-term plasticity at inhibitory synapses. Current Opinion In Neurobiology 2011, 21: 328-338. PMID: 21334194, PMCID: PMC3092861, DOI: 10.1016/j.conb.2011.01.006.Peer-Reviewed Original ResearchConceptsSynaptic plasticityInhibitory synaptic plasticityModification of neural circuitsNeural circuitsNeural circuit refinementNeural circuit functionGABAergic plasticityRegulate excitabilityExcitatory/inhibitory balanceInhibitory plasticityCircuit refinementExcitatory synapsesLong-term plasticitySynaptic efficacyFunctional relevanceCircuit functionDiverse mechanismsLTP/LTDEfficacySynapses
2010
Dopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex
Chiu C, Puente N, Grandes P, Castillo P. Dopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex. Journal Of Neuroscience 2010, 30: 7236-7248. PMID: 20505090, PMCID: PMC2905527, DOI: 10.1523/jneurosci.0736-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBenzoxazinesCannabinoid Receptor ModulatorsChelating AgentsDopamineDopamine AgentsEgtazic AcidEndocannabinoidsFemaleGamma-Aminobutyric AcidIn Vitro TechniquesInhibitory Postsynaptic PotentialsIsoquinolinesMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionMorpholinesNaphthalenesNeuronal PlasticityPatch-Clamp TechniquesPiperidinesPrefrontal CortexProtein Kinase InhibitorsPyrazolesRatsRats, WistarReceptor, Cannabinoid, CB1Receptors, Dopamine D2Silver StainingSulfonamidesSynapsesConceptsPrefrontal cortexI-LTDECB-mediated long-term depressionLong-term depression of inhibitory transmissionPrefrontal cortex of ratsDopamine type 2 receptorPrefrontal cortical functionEndocannabinoid-mediated plasticityEndogenous cannabinoid receptorsGroup I metabotropic glutamate receptorsCannabinoid receptor systemSuppress GABA releaseECB signalingECB-LTDWorking memoryDopaminergic modulationCannabinoid receptorsBrain regionsGABA releaseDopamineEmotional learningCortical functionInhibitory transmissionGABAergic synapsesElectrophysiological evidence
2008
RIM1α and RIM1β Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions
Kaeser P, Kwon H, Chiu C, Deng L, Castillo P, Südhof T. RIM1α and RIM1β Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions. Journal Of Neuroscience 2008, 28: 13435-13447. PMID: 19074017, PMCID: PMC2701653, DOI: 10.1523/jneurosci.3235-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsExcitatory Postsynaptic PotentialsGTP-Binding ProteinsHippocampusMiceMice, KnockoutNeuronal PlasticityNeurotransmitter AgentsOrgan Culture TechniquesPatch-Clamp TechniquesPresynaptic TerminalsPromoter Regions, GeneticProtein IsoformsReverse Transcriptase Polymerase Chain ReactionSynapsesSynaptic TransmissionSynaptic VesiclesConceptsRIM1 geneActive zone proteinsKnock-out miceSynaptic vesicle primingPresynaptic long-term plasticitySynaptic vesicle proteinsNeurotransmitter releaseLong-term presynaptic plasticityVesicle primingActive zoneMultidomain proteinsSynaptotagmin-1Vesicle proteinsRIM1alphaN-terminusRIM1Plasma membranePresynaptic plasticityDeletionGenesSynaptic functionPresynaptic terminalsProteinIsoformsShort-term synaptic plasticity
2003
Synaptic Modification by Vision
Chiu C, Weliky M. Synaptic Modification by Vision. Science 2003, 300: 1890-1891. PMID: 12817134, DOI: 10.1126/science.1086934.Peer-Reviewed Original Research