2023
Microbiota and Diapause-Induced Neuroprotection Share a Dependency on Calcium But Differ in Their Effects on Mitochondrial Morphology
Delgado S, Urrutia A, Gutzwiller F, Chiu C, Calixto A. Microbiota and Diapause-Induced Neuroprotection Share a Dependency on Calcium But Differ in Their Effects on Mitochondrial Morphology. ENeuro 2023, 10: eneuro.0424-22.2023. PMID: 37385728, PMCID: PMC10368204, DOI: 10.1523/eneuro.0424-22.2023.Peer-Reviewed Original ResearchConceptsCaenorhabditis elegans</i>Length of mitochondriaDiapause entryLactate-producing bacteriaReverse geneticsGut microbiotaMitochondrial morphologyTranscriptomic approachMitochondrial sizeMitochondrial functionMicrobiotaMechanistic commonalitiesEnvironmental variablesBacteriaMCU-1GenesNeuronal functionMultiple mechanismsCalcium homeostasisDiapauseNeuronal degenerationNeuronal protectionRegeneration of damaged neuronsFood deprivationTranscriptome
2008
RIM1α and RIM1β Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions
Kaeser P, Kwon H, Chiu C, Deng L, Castillo P, Südhof T. RIM1α and RIM1β Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions. Journal Of Neuroscience 2008, 28: 13435-13447. PMID: 19074017, PMCID: PMC2701653, DOI: 10.1523/jneurosci.3235-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsExcitatory Postsynaptic PotentialsGTP-Binding ProteinsHippocampusMiceMice, KnockoutNeuronal PlasticityNeurotransmitter AgentsOrgan Culture TechniquesPatch-Clamp TechniquesPresynaptic TerminalsPromoter Regions, GeneticProtein IsoformsReverse Transcriptase Polymerase Chain ReactionSynapsesSynaptic TransmissionSynaptic VesiclesConceptsRIM1 geneActive zone proteinsKnock-out miceSynaptic vesicle primingPresynaptic long-term plasticitySynaptic vesicle proteinsNeurotransmitter releaseLong-term presynaptic plasticityVesicle primingActive zoneMultidomain proteinsSynaptotagmin-1Vesicle proteinsRIM1alphaN-terminusRIM1Plasma membranePresynaptic plasticityDeletionGenesSynaptic functionPresynaptic terminalsProteinIsoformsShort-term synaptic plasticity