Dysfunctional monocytic toll-like receptor 4 signaling pathway and cognitive deficits in chronic schizophrenia patients with tardive dyskinesia
Li N, Li Y, Huang J, Zhang P, Tong J, Chen S, Cui Y, Tan S, Wang Z, Yang F, Hong E, Li CR, Tian L, Tan Y. Dysfunctional monocytic toll-like receptor 4 signaling pathway and cognitive deficits in chronic schizophrenia patients with tardive dyskinesia. Neuroscience Letters 2022, 777: 136581. PMID: 35337952, DOI: 10.1016/j.neulet.2022.136581.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Abnormal Involuntary Movement ScaleTardive dyskinesiaChronic schizophrenia patientsSchizophrenia patientsMATRICS Consensus Cognitive BatteryReceptor 4TD patientsHigher toll-like receptor 4Cognitive deficitsSeverity of TDNegative Syndrome ScaleInnate immune systemNTD patientsTLR4 levelsHealthy controlsAIMS scoresMovement ScalePatientsConsensus Cognitive BatteryLPS stimulationTLR4 signalsPathway disturbancesLipopolysaccharide (LPS) stimulationSyndrome Scale