2022
Cerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Cerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort. Journal Of Alzheimer's Disease 2022, 85: 1251-1265. PMID: 34924392, PMCID: PMC9215906, DOI: 10.3233/jad-215316.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseInferior frontal gyrusIndependent cohortEmotional scoresHealthy controlsCognitive impairmentVolumetric correlatesMini-Mental State Examination scoreAD/mild cognitive impairmentNeuroanatomical correlatesState Examination scoreApathy Evaluation ScaleGray matter volumeVoxel-based morphometryRight inferior frontal gyrusLabel-based reviewMild cognitive impairmentNormal older adultsCortical atrophyHigh morbidityBasal gangliaRight putamenMatter volumeAnterior cingulateReduced quality
2014
The effects of age on resting state functional connectivity of the basal ganglia from young to middle adulthood
Manza P, Zhang S, Hu S, Chao HH, Leung HC, Li CS. The effects of age on resting state functional connectivity of the basal ganglia from young to middle adulthood. NeuroImage 2014, 107: 311-322. PMID: 25514518, PMCID: PMC4300261, DOI: 10.1016/j.neuroimage.2014.12.016.Peer-Reviewed Original ResearchConceptsBasal gangliaNegative connectivityFunctional connectivityState functional magnetic resonanceBasal ganglia nucleiCerebral functional connectivityVentral tegmental area/substantia nigraState functional connectivityAge-related structural changesYears of agePosterior cingulate cortexMedial orbitofrontal cortexDefault mode network regionsFunctional magnetic resonanceCerebellum changesEffect of ageCerebral cortexDopaminergic dysfunctionSubstantia nigraPosterior putamenSomatomotor cortexAdults 18Motor functionVTA/SNMiddle adulthood
2009
Functional Connectivity Delineates Distinct Roles of the Inferior Frontal Cortex and Presupplementary Motor Area in Stop Signal Inhibition
Duann JR, Ide JS, Luo X, Li CS. Functional Connectivity Delineates Distinct Roles of the Inferior Frontal Cortex and Presupplementary Motor Area in Stop Signal Inhibition. Journal Of Neuroscience 2009, 29: 10171-10179. PMID: 19675251, PMCID: PMC2769086, DOI: 10.1523/jneurosci.1300-09.2009.Peer-Reviewed Original ResearchConceptsMotor response inhibitionBasal ganglia circuitryPresupplementary motor areaInferior prefrontal cortexStop-signal inhibitionMotor areaRight inferior prefrontal cortexPrefrontal cortexResponse inhibitionSignal inhibitionRecent imaging literaturePrimary motor cortexMedial prefrontal cortexInferior frontal cortexMotor cortexFrontal cortexCortical areasPrimary siteVentral attention systemPreSMAGreater effective connectivityCortexFunctional interconnectivityPsychophysiological interactionGo trials
2008
Subcortical processes of motor response inhibition during a stop signal task
Li CS, Yan P, Sinha R, Lee TW. Subcortical processes of motor response inhibition during a stop signal task. NeuroImage 2008, 41: 1352-1363. PMID: 18485743, PMCID: PMC2474693, DOI: 10.1016/j.neuroimage.2008.04.023.Peer-Reviewed Original ResearchConceptsMotor response inhibitionSubthalamic nucleusStop-signal reaction timeStop-signal taskResponse inhibitionShorter stop-signal reaction timesSignal inhibitionMagnetic resonance imaging studyGreater activationLonger stop-signal reaction timesSignal taskResonance imaging studyFunctional magnetic resonance imaging studySubcortical processesStop-signal inhibitionGroups of subjectsSubthalamic activityBasal gangliaSignal reaction timeThalamic nucleiCaudate headImaging studiesStop trialsMedial prefrontal activityCortical mechanisms