2020
Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype.
Guo X, Fu Y, Zhang Y, Wang T, Lu L, Luo X, Wang K, Huang J, Xie T, Zheng C, Yang K, Tong J, Zuo L, Kang L, Tan Y, Jiang K, Li CR, Luo X. Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype. 2020, 4 PMID: 34046650, PMCID: PMC8153461.Peer-Reviewed Original ResearchMajor psychiatric disordersGenome-wide association studiesL-type voltage-gated calcium channelsMajor depressive disorderMRNA expression regulationPsychiatric disordersTherapeutic targetBipolar disorderChronic mild stress (CMS) ratsHuman hippocampusExpression regulationDepressive endophenotypeType voltage-gated calcium channelsRole of venlafaxineVoltage-gated calcium channelsPotential therapeutic targetRisk genesSignificant mRNA expressionVenlafaxine treatmentDepressive disorderStress ratsDepressive symptomsIndependent cohortCalcium channelsMRNA expression
2017
Combined reality therapy and mindfulness meditation decrease intertemporal decisional impulsivity in young adults with Internet gaming disorder
Yao Y, Chen P, Li C, Hare T, Li S, Zhang J, Liu L, Ma S, Fang X. Combined reality therapy and mindfulness meditation decrease intertemporal decisional impulsivity in young adults with Internet gaming disorder. Computers In Human Behavior 2017, 68: 210-216. DOI: 10.1016/j.chb.2016.11.038.Peer-Reviewed Original ResearchDecisional impulsivityIGD subjectsHC subjectsTherapeutic targetYoung adultsInternet gaming disorderEnd of interventionPossible therapeutic targetReality therapyGroup behavioral interventionIGD severityMindfulness meditationBehavioral interventionsTherapySimilar time periodGaming disorderInterventionBalloon Analogue Risk TaskBaseline testBaselineSubjectsSeverityDisordersAdultsImpulsivity