Hypothalamic connectivities predict individual differences in ADT-elicited changes in working memory and quality of life in prostate cancer patients
Chaudhary S, Roy A, Summers C, Zhornitsky S, Ahles T, Li CR, Chao HH. Hypothalamic connectivities predict individual differences in ADT-elicited changes in working memory and quality of life in prostate cancer patients. Scientific Reports 2022, 12: 9567. PMID: 35688928, PMCID: PMC9187668, DOI: 10.1038/s41598-022-13361-4.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyProstate cancer patientsQuality of lifeCancer patientsCorrect response rateMonths of ADTLong-term androgen deprivation therapyResponse rateNon-metastatic prostate cancerMontreal Cognitive Assessment scoreProspective observational studyState functional connectivityCognitive Assessment scoreDeprivation therapyHypothalamic connectivityAndrogen deprivationPrognostic markerProstate cancerGonadal axisObservational studyYears of educationQOL effectsControl groupQoLSalience network