2024
Deficient sleep, altered hypothalamic functional connectivity, depression and anxiety in cigarette smokers
Chen Y, Chaudhary S, Li G, Fucito L, Bi J, Li C. Deficient sleep, altered hypothalamic functional connectivity, depression and anxiety in cigarette smokers. Neuroimage Reports 2024, 4: 100200. PMID: 38605733, PMCID: PMC11008573, DOI: 10.1016/j.ynirp.2024.100200.Peer-Reviewed Original ResearchResting state functional connectivitySeverity of depressionPittsburgh Sleep Quality IndexMotivated behaviorNicotine dependenceFunctional connectivityPittsburgh Sleep Quality Index scoreAchenbach Adult Self-ReportSeverity of alcohol useAssociated with greater severityComorbid nicotine dependenceDeficient sleepAdult Self-ReportHypothalamic functional connectivityHuman Connectome ProjectAnxiety disordersAnxiety severityPublished routinesAnxiety symptomsCircuit dysfunctionGreater severityPsychiatric problemsSleep-wake cyclePoor sleep qualityNeural markers
2023
Overnight Abstinence, Ventrostriatal-Insular Connectivity, and Tridimensional Personality Traits in Cigarette Smokers
Chen Y, Li C. Overnight Abstinence, Ventrostriatal-Insular Connectivity, and Tridimensional Personality Traits in Cigarette Smokers. Journal Of Integrative Neuroscience 2023, 22: 66. PMID: 37258442, DOI: 10.31083/j.jin2203066.Peer-Reviewed Original ResearchConceptsPersonality traitsOvernight abstinenceTridimensional Personality QuestionnaireState functional magnetic resonance imaging scansFunctional magnetic resonance imaging (fMRI) scansPersonality risk factorsIndividual personality traitsMagnetic resonance imaging (MRI) scansState functional connectivityShort-term abstinenceResonance imaging scansRisk of smokingInter-regional connectivityNicotine deprivationHarm avoidanceConnectivity correlatesNeural markersCigarette smokingFunctional connectivityCigarette smokersPersonality QuestionnaireImaging scansRisk factorsDorsal striatumNicotine dependence
2021
Mapping cortical and subcortical asymmetries in substance dependence: Findings from the ENIGMA Addiction Working Group
Cao Z, Ottino‐Gonzalez J, Cupertino RB, Schwab N, Hoke C, Catherine O, Cousijn J, Dagher A, Foxe JJ, Goudriaan AE, Hester R, Hutchison K, Li C, London ED, Lorenzetti V, Luijten M, Martin‐Santos R, Momenan R, Paulus MP, Schmaal L, Sinha R, Sjoerds Z, Solowij N, Stein DJ, Stein EA, Uhlmann A, van Holst R, Veltman DJ, Wiers RW, Yücel M, Zhang S, Jahanshad N, Thompson PM, Conrod P, Mackey S, Garavan H. Mapping cortical and subcortical asymmetries in substance dependence: Findings from the ENIGMA Addiction Working Group. Addiction Biology 2021, 26: e13010. PMID: 33508888, PMCID: PMC8317852, DOI: 10.1111/adb.13010.Peer-Reviewed Original ResearchConceptsENIGMA Addiction Working GroupSubstance dependenceBrain asymmetrySubstance-specific effectsAltered brain structureNondependent participantsStructural brain asymmetrySubcortical asymmetriesNucleus accumbensNicotine dependencePsychiatric diagnosisSubcortical regionsAlcohol dependenceWorking GroupBrain phenotypesBrain structuresVolume asymmetryHemispheric differentiationIndividualsParticipantsPrevious studiesMRI datasetsGroupAccumbensFindings
2016
Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence
Zuo L, Tan Y, Li C, Wang Z, Wang K, Zhang X, Lin X, Chen X, Zhong C, Wang X, Wang J, Lu L, Luo X. Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 171: 1057-1071. PMID: 27473937, PMCID: PMC5587505, DOI: 10.1002/ajmg.b.32476.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAnimalsBlack or African AmericanCase-Control StudiesDatabases, Nucleic AcidFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMaleMiceNicotinePolymorphism, Single NucleotideReceptors, NicotinicTobacco Use DisorderWhite PeopleConceptsCHRN genesGenomic regionsNicotine dependenceAD risk genesAlcohol dependenceRare variantsNicotinic cholinergic receptor genesRewarding effectsDistinct subunitsMouse brainGenesMicroarray platformRisk genesNicotine's rewarding effectsCholinergic receptor genesReceptor geneSpecific brain areasDifferent neuropsychiatric disordersIndependent cohortDiscrete regionsWhole mouse brainBrain areasNeuropsychiatric disordersMRNA expressionBrain
2013
Neural Bases of Pharmacological Treatment of Nicotine Dependence - Insights from Functional Brain Imaging: A Systematic Review
Menossi HS, Goudriaan AE, de Azevedo-Marques Périco C, Nicastri S, de Andrade AG, D’Elia G, Li CS, Castaldelli-Maia JM. Neural Bases of Pharmacological Treatment of Nicotine Dependence - Insights from Functional Brain Imaging: A Systematic Review. CNS Drugs 2013, 27: 921-941. PMID: 23853032, DOI: 10.1007/s40263-013-0092-8.Peer-Reviewed Original ResearchConceptsPharmacological treatmentNicotine dependenceContinuous arterial spin labelingCingulate cortexPharmacological smoking cessation treatmentsBlood oxygen level-dependent imagingNicotine replacement therapyPositron emission tomography studySmoking cessation treatmentEffects of vareniclineMaintenance of smokingLevel-dependent imagingNicotine-dependent individualsEmission tomography studiesMore effective treatmentsFunctional magnetic resonance imagingMagnetic resonance imagingPosterior cingulate cortexArterial spin labelingWeb of ScienceLateral orbitofrontal cortexSynthesis MethodsTwoClinical characteristicsData sourcesWeNicotine replacement