2024
Serum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders
Li Y, Wang L, Huang J, Zhang P, Zhou Y, Tong J, Chen W, Gou M, Tian B, Li W, Luo X, Tian L, Hong L, Li C, Tan Y. Serum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders. Frontiers In Psychiatry 2024, 15: 1357293. PMID: 38680780, PMCID: PMC11046465, DOI: 10.3389/fpsyt.2024.1357293.Peer-Reviewed Original ResearchYoung Mania Rating ScaleBD-DAffective disordersBD-MDepressive symptomsHamilton Depression Scale-17 itemsRemission of depressive symptomsKynurenic acidMania Rating ScaleAcute manic episodeWeeks of antidepressantsRisk of MDDKynurenine pathwayAssociated with remissionAntipsychotic medicationDisrupt tryptophan metabolismManic symptomsDepressive disorderBD-D.Depressive episodeHAMD-17Mood stabilizersManic episodesBipolar disorderTryptophan pathway
2023
Role of the immune-kynurenine pathway in treatment-resistant schizophrenia
Chen W, Tian Y, Gou M, Wang L, Tong J, Zhou Y, Feng W, Li Y, Chen S, Liu Y, Wang Z, Pan S, Zhang P, Huang J, Yang X, Li C, Tian L, Hong L, Tan Y. Role of the immune-kynurenine pathway in treatment-resistant schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2023, 130: 110926. PMID: 38147973, DOI: 10.1016/j.pnpbp.2023.110926.Peer-Reviewed Original ResearchConceptsImmune-inflammatory response systemTreatment-resistant schizophreniaQUIN/KYNA ratioNon-TRS patientsHealthy controlsKynurenine pathwayKP metabolismKP activationKynurenic acidQuinolinic acidInflammation-related effectsPeripheral immune responseAnti-inflammatory cytokinesPro-inflammatory cytokinesBinary logistic regression analysisPathophysiology of schizophreniaLogistic regression analysisAge of onsetLower kynurenineKP metabolitesKYNA levelsIllness onsetPlasma levelsRisk factorsNMDA receptors
2022
Associations of the serum kynurenine pathway metabolites with P50 auditory gating in non-smoking patients with first-episode schizophrenia
Yang Q, Zhang Y, Yang K, Niu Y, Fan F, Chen S, Luo X, Tan S, Wang Z, Tong J, Yang F, Li C, Tan Y. Associations of the serum kynurenine pathway metabolites with P50 auditory gating in non-smoking patients with first-episode schizophrenia. Frontiers In Psychiatry 2022, 13: 1036421. PMID: 36339840, PMCID: PMC9632432, DOI: 10.3389/fpsyt.2022.1036421.Peer-Reviewed Original ResearchFirst-episode schizophreniaP50 auditory gatingNon-smoking patientsHealthy controlsAuditory gatingSerum kynurenineSerum levelsS2/S1 ratioAcid levelsKynurenine pathway metabolitesFirst-episode patientsNegative Syndrome ScaleKynurenine acidEpisode patientsNeuroactive metabolitesKynurenine pathwayPatientsS1 ratioSyndrome ScaleCognitive impairmentS1-S2SchizophreniaPathway metabolitesS1 amplitudeKynurenine