2024
Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches
Yang B, Xiang B, Wang T, Ma S, Li C. Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches. Psychiatry Research 2024, 334: 115815. PMID: 38422867, PMCID: PMC11017751, DOI: 10.1016/j.psychres.2024.115815.Peer-Reviewed Original ResearchConceptsMediodorsal nucleus of the thalamusMedial prefrontal cortexPrefrontal cortexNeurogenetic underpinningsDorsolateral prefrontal cortexBrain transcriptomeDrug memoryOrbitofrontal cortexInhibitory controlSmoking severityAssociated with CPDHuman brain transcriptomeMediodorsal nucleusWhole-brainNeurogenetic mechanismsPrimary motor cortexMechanisms of individual variationCortexHub proteinsGenetic riskAmygdalaStriatumMotor cortexOPFCHippocampus
2019
The dorsolateral prefrontal cortex is selectively involved in chemotherapy-related cognitive impairment in breast cancer patients with different hormone receptor expression.
Chen H, Ding K, Zhao J, Chao HH, Li CR, Cheng H. The dorsolateral prefrontal cortex is selectively involved in chemotherapy-related cognitive impairment in breast cancer patients with different hormone receptor expression. American Journal Of Cancer Research 2019, 9: 1776-1785. PMID: 31497358, PMCID: PMC6726991.Peer-Reviewed Original ResearchChemotherapy-related cognitive impairmentBreast cancer patientsHormone receptor expressionDorsolateral prefrontal cortexLeft dorsolateral prefrontal cortexCancer patientsSuperior frontal gyrusReceptor expressionFunctional connectivityPrefrontal cortexEstrogen receptorLeft precuneusCognitive impairmentFunctional magnetic resonance imaging (fMRI) examinationsMagnetic resonance imaging examinationsRight superior frontal gyrusNeuropsychological testsRight dorsolateral prefrontal cortexFunctional connectivity strengthResting-state fMRI dataER-/PRBC patientsDLPFC connectivityBreast cancerImaging examinations
2018
Structural and functional cerebral bases of diminished inhibitory control during healthy aging
Hu S, Ide JS, Chao HH, Castagna B, Fischer KA, Zhang S, Li C. Structural and functional cerebral bases of diminished inhibitory control during healthy aging. Human Brain Mapping 2018, 39: 5085-5096. PMID: 30113124, PMCID: PMC6287913, DOI: 10.1002/hbm.24347.Peer-Reviewed Original ResearchConceptsProlonged stop signal reaction timeStop-signal reaction timeAge-related reductionInhibitory controlFunctional changesPrefrontal cortexAge-related diminutionSignal taskRight dorsolateral prefrontal cortexSame brain regionsFunctional magnetic resonance imagingMagnetic resonance imagingMedial prefrontal cortexInferior parietal cortexResponse inhibitionDorsolateral prefrontal cortexInferior frontal cortexDiminished inhibitory controlCerebral changesStructure-function associationsSignal reaction timeCaudate headAge-related differencesStop-signal taskFrontal cortexResting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study
Zhang S, Wang W, Zhornitsky S, Li CR. Resting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study. Frontiers In Psychiatry 2018, 9: 344. PMID: 30100886, PMCID: PMC6072838, DOI: 10.3389/fpsyt.2018.00344.Peer-Reviewed Original ResearchState functional connectivityMedial hypothalamusHealthy controlsCocaine dependenceDorsolateral prefrontal cortexFunctional connectivityHypothalamic connectivityPrefrontal cortexVentral striatumCocaine misuseConnectivity strengthCocaine Craving QuestionnaireRole of dopamineInferior parietal lobuleLateral hypothalamusTrend-level significanceMesocorticolimbic circuitPreclinical workHypothalamusVentromedial prefrontal cortexCocaine usePast monthParietal lobuleTemporal gyrusHypothalamus functionsThe Comorbidity Between Internet Gaming Disorder and Depression: Interrelationship and Neural Mechanisms
Liu L, Yao YW, Li CR, Zhang JT, Xia CC, Lan J, Ma SS, Zhou N, Fang XY. The Comorbidity Between Internet Gaming Disorder and Depression: Interrelationship and Neural Mechanisms. Frontiers In Psychiatry 2018, 9: 154. PMID: 29740358, PMCID: PMC5924965, DOI: 10.3389/fpsyt.2018.00154.Peer-Reviewed Original ResearchInternet gaming disorderDorsolateral prefrontal cortexNeural mechanismsLeft amygdalaGaming disorderRight dorsolateral prefrontal cortexDepression symptomsPrecentral gyrusAutoregressive cross-lagged modelingBrain imaging researchExecutive control networkResting-state functional connectivity studyCross-lagged modelingFunctional connectivity studiesLongitudinal survey studyNeural levelBrain mechanismsEmotional deficitsPrefrontal cortexCognitive deficitsPsychotherapy interventionsControl participantsIGD severityCollege studentsConnectivity studies
2013
Effects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study
Chao HH, Hu S, Ide JS, Uchio E, Zhang S, Rose M, Concato J, Li CS. Effects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study. PLOS ONE 2013, 8: e72032. PMID: 23977199, PMCID: PMC3747074, DOI: 10.1371/journal.pone.0072032.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyProstate cancer patientsGray matter volumeMagnetic resonance imagingPrimary motor cortexCancer patientsVoxel-based morphometryMatter volumeMotor cortexProstate cancerEffects of ADTLow-risk prostate cancerCerebral gray matter volumeStatistical Parametric Mapping 8Utility of brainControl participantsHigh-resolution magnetic resonance imagingPotential side effectsQuality of lifeResolution magnetic resonance imagingSame time pointsFunctional magnetic resonance imagingHigh-resolution T1Prefrontal cortical activationDorsolateral prefrontal cortexGray matter volume correlates of global positive alcohol expectancy in non‐dependent adult drinkers
Ide JS, Zhang S, Hu S, Matuskey D, Bednarski SR, Erdman E, Farr OM, Li C. Gray matter volume correlates of global positive alcohol expectancy in non‐dependent adult drinkers. Addiction Biology 2013, 19: 895-906. PMID: 23461484, PMCID: PMC3681829, DOI: 10.1111/adb.12046.Peer-Reviewed Original ResearchConceptsGM volumeVoxel-based morphometrySuperior frontal gyrusPrecentral gyrusBilateral superior frontal gyrusBilateral dorsolateral prefrontal cortexStructural brain changesNumerous imaging studiesLeft precentral gyrusGray matter volumeDrinking behaviorRight ventral putamenDorsolateral prefrontal cortexNon-dependent drinkersStructural brain correlatesVentral putamenBrain changesFrontal cortexGray matter correlatesMatter volumeNon-dependent drinkingRecent drinkingImaging studiesInfluence drinking behaviorPrefrontal cortex
2012
Decreased saliency processing as a neural measure of Barratt impulsivity in healthy adults
Farr OM, Hu S, Zhang S, Li CS. Decreased saliency processing as a neural measure of Barratt impulsivity in healthy adults. NeuroImage 2012, 63: 1070-1077. PMID: 22885245, PMCID: PMC3472158, DOI: 10.1016/j.neuroimage.2012.07.049.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeStop-signal taskMiddle frontal cortexCognitive controlTrait impulsivityResponse inhibitionComponent processesSaliency processingBarratt impulsivityCognitive control functionsLeft dorsolateral prefrontal cortexPost-error slowingRegional brain activationDorsolateral prefrontal cortexSignal reaction timeYoung adult participantsBarratt Impulsivity ScaleNeural measuresError processingSignal taskBrain activationPsychophysiological interactionImpulsivity scoresBIS-11Impulsivity Scale
2009
Altered Impulse Control in Alcohol Dependence: Neural Measures of Stop Signal Performance
Li C, Luo X, Yan P, Bergquist K, Sinha R. Altered Impulse Control in Alcohol Dependence: Neural Measures of Stop Signal Performance. Alcohol Clinical And Experimental Research 2009, 33: 740-750. PMID: 19170662, PMCID: PMC2697053, DOI: 10.1111/j.1530-0277.2008.00891.x.Peer-Reviewed Original ResearchConceptsHealthy control subjectsFunctional magnetic resonance imagingAlcohol dependencePost-error behavioral adjustmentDorsolateral prefrontal cortexAlcohol urgesTrial reaction timePost-error slowingPrefrontal cortexLeft dorsolateral prefrontal cortexRight dorsolateral prefrontal cortexMagnetic resonance imagingImpulse controlStatistical parametric mappingStop errorAbstinent patientsControl subjectsNovel pharmacotherapiesSignal reaction timeTreatment outcomesFrontal cortexHC subjectsResonance imagingBehavioral adjustmentSubcortical structures