2020
Cortical Thickness in Alcohol Dependent Patients With Apathy
Yang K, Yang Q, Niu Y, Fan F, Chen S, Luo X, Tan S, Wang Z, Tong J, Yang F, Le TM, Li CR, Tan Y. Cortical Thickness in Alcohol Dependent Patients With Apathy. Frontiers In Psychiatry 2020, 11: 364. PMID: 32431630, PMCID: PMC7214693, DOI: 10.3389/fpsyt.2020.00364.Peer-Reviewed Original ResearchInferior parietal cortexHealthy controlsCortical thicknessSuperior parietal cortexOccipito-temporal cortexParietal cortexOccipital gyrusBilateral superior parietal cortexCritical clinical featuresStructural brain changesEducation-matched healthy controlsSeverity of apathyRight superior occipital gyrusAlcohol-dependent patientsBilateral lingual gyrusLeft middle occipital gyrusSuperior occipital gyrusMiddle occipital gyrusBilateral inferior parietal cortexOccipital-temporal cortexClinical featuresDependent patientsRight intraparietal sulcusMagnetic resonance imaging dataBrain changes
2010
Association of Frontal and Posterior Cortical Gray Matter Volume With Time to Alcohol Relapse: A Prospective Study
Rando K, Hong KI, Bhagwagar Z, Li CS, Bergquist K, Guarnaccia J, Sinha R. Association of Frontal and Posterior Cortical Gray Matter Volume With Time to Alcohol Relapse: A Prospective Study. American Journal Of Psychiatry 2010, 168: 183-192. PMID: 21078704, PMCID: PMC3668974, DOI: 10.1176/appi.ajp.2010.10020233.Peer-Reviewed Original ResearchConceptsGray matter volume deficitsGray matter volumeAlcohol-dependent patientsMatter volumeVolume deficitsAlcohol relapseRelapse riskComparison subjectsBrain regionsCortical gray matter volumeAlcohol useRegional brain volume differencesSmaller gray matter volumePoor clinical outcomeBrain volume deficitsFrontal gray matter volumeGray matter atrophyAbstinent alcohol-dependent patientsAlcoholism treatment outcomeHigh-resolution structural MRIProspective study designHealthy comparison subjectsVoxel-based morphometryAlcohol-dependent groupMonths of abstinence
2009
Decreased Amygdala Activation during Risk Taking in Non-Dependent Habitual Alcohol Users: A Preliminary fMRI Study of the Stop Signal Task
Yan P, Li CS. Decreased Amygdala Activation during Risk Taking in Non-Dependent Habitual Alcohol Users: A Preliminary fMRI Study of the Stop Signal Task. The American Journal Of Drug And Alcohol Abuse 2009, 35: 284-289. PMID: 19579091, PMCID: PMC4511157, DOI: 10.1080/00952990902968569.Peer-Reviewed Original ResearchConceptsStop-signal taskAlcohol drinkersAmygdala activationAlcohol dependenceNon-dependent social drinkersInhibitory controlAlcohol useHabitual alcohol useHeavy alcohol drinkersSignal taskAlcohol-dependent patientsPreliminary fMRI studyAltered brain activationFunctional magnetic resonance imagingMagnetic resonance imagingDependent patientsNeural processesHabitual drinkingHealthy controlsCurrent preliminary studyAlcohol usersResonance imagingStop trialsLight drinkersKey neural processes