2014
Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip
Sheng W, Ogunwobi O, Chen T, Zhang J, George T, Liu C, Fan Z. Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip. Lab On A Chip 2014, 14: 89-98. PMID: 24220648, PMCID: PMC3918168, DOI: 10.1039/c3lc51017d.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ImmobilizedAntigens, NeoplasmAntineoplastic AgentsCell Adhesion MoleculesCell Line, TumorCell SeparationCell SurvivalEpithelial Cell Adhesion MoleculeHumansLeukocyte Common AntigensMaleMicrofluidic Analytical TechniquesNeoplastic Cells, CirculatingPancreatic NeoplasmsTomography, X-Ray ComputedConceptsHigh-performance microchipsMicromixer structurePresented technologyReal-time monitoringChannel geometryFlow rateTransverse flowCapture efficiencyChipDevicesCell capturePersonalized therapeutic treatmentsTumor cell captureAntibody-coated surfaceGreat promiseSpiked tumor cellsIsolation of CTCsWide rangeCancer patients' blood
2012
Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer
Meng L, Yang L, Zhao X, Zhang L, Zhu H, Liu C, Tan W. Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer. PLOS ONE 2012, 7: e33434. PMID: 22558072, PMCID: PMC3338807, DOI: 10.1371/journal.pone.0033434.Peer-Reviewed Original ResearchConceptsAptamer-drug conjugatesCancer-specific aptamersAntitumor agent doxorubicinDOX conjugatesIntercalation methodAptamerCell viability testTargeted deliveryConjugatesCancer cellsTarget proteinsAgent doxorubicinPotential candidateCell linesDOXEfficiency of chemotherapyLiver cancer cellsNonspecific uptakeTarget specificityAvailable aptamersCarcinoma cell linesChemotherapy agentsHepatocellular carcinoma cell linesHuman hepatocellular carcinoma cell linePromising method