2008
A Role for TNF Receptor Type II in Leukocyte Infiltration into the Lung during Experimental Idiopathic Pneumonia Syndrome
Hildebrandt G, Olkiewicz K, Corrion L, Clouthier S, Pierce E, Liu C, Cooke K. A Role for TNF Receptor Type II in Leukocyte Infiltration into the Lung during Experimental Idiopathic Pneumonia Syndrome. Transplantation And Cellular Therapy 2008, 14: 385-396. PMID: 18342780, PMCID: PMC2390587, DOI: 10.1016/j.bbmt.2008.01.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchoalveolar Lavage FluidFemaleGraft SurvivalGraft vs Host DiseaseLungMiceMice, Inbred C57BLMice, Inbred StrainsPneumoniaReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIStem Cell TransplantationSyndromeTransplantation, HomologousTumor Necrosis Factor-alphaConceptsIdiopathic pneumonia syndromeTNF-alphaPneumonia syndromeAllo-SCTLeukocyte infiltrationPulmonary vascular endothelial cell apoptosisBronchoalveolar lavage fluid levelsExperimental Idiopathic Pneumonia SyndromePulmonary ICAM-1 expressionWild-type B6 miceAllogeneic stem cell transplantationTNF receptor type IIType II TNF receptorLavage fluid levelsStem cell transplantationICAM-1 expressionVascular endothelial cell apoptosisReceptor type IIMHC class IEndothelial cell apoptosisDonor leukocytesFatal complicationPulmonary inflammationSyngeneic donorsWT mice
2004
Blockade of CXCR3 Receptor:Ligand Interactions Reduces Leukocyte Recruitment to the Lung and the Severity of Experimental Idiopathic Pneumonia Syndrome
Hildebrandt G, Corrion L, Olkiewicz K, Lu B, Lowler K, Duffner U, Moore B, Kuziel W, Liu C, Cooke K. Blockade of CXCR3 Receptor:Ligand Interactions Reduces Leukocyte Recruitment to the Lung and the Severity of Experimental Idiopathic Pneumonia Syndrome. The Journal Of Immunology 2004, 173: 2050-2059. PMID: 15265940, DOI: 10.4049/jimmunol.173.3.2050.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsBronchoalveolar Lavage FluidCells, CulturedChemokine CXCL10Chemokine CXCL9Chemokines, CXCChemotaxis, LeukocyteCrosses, GeneticFemaleHematopoietic Stem Cell TransplantationInterferon-gammaLigandsLungLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutPneumoniaReceptors, CCR5Receptors, ChemokineReceptors, CXCR3SpleenT-Lymphocytes, CytotoxicTransplantation, HomologousTumor Necrosis Factor-alphaConceptsIdiopathic pneumonia syndromeDonor T cellsPneumonia syndromeIP-10TNF-alphaT cellsIFN-gammaCXCR3 receptorDevelopment of IPSExperimental Idiopathic Pneumonia SyndromeIP-10 protein levelsAllogeneic stem cell transplantationAllo-SCT recipientsInfiltration of IFNStandard immunosuppressive therapyT cell subsetsBronchoalveolar lavage fluidStem cell transplantationT cell recruitmentControl-treated animalsImmunosuppressive therapyLigand MigAllo-SCTFatal complicationLung injury
2003
A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation
Hildebrandt G, Duffner U, Olkiewicz K, Corrion L, Willmarth N, Williams D, Clouthier S, Hogaboam C, Reddy P, Moore B, Kuziel W, Liu C, Yanik G, Cooke K. A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood 2003, 103: 2417-2426. PMID: 14615370, DOI: 10.1182/blood-2003-08-2708.Peer-Reviewed Original ResearchConceptsMonocyte chemoattractant protein-1Idiopathic pneumonia syndromeAllogeneic bone marrow transplantationBone marrow transplantationChemokine receptor 2CCR2/MCPAllo-BMTPneumonia syndromeMarrow transplantationBronchoalveolar lavage fluid cellularityExperimental Idiopathic Pneumonia SyndromeBAL fluid levelsMouse BMT modelSoluble p55 TNF receptorTime of diagnosisPreliminary clinical findingsChemoattractant protein-1P55 TNF receptorDonor leukocytesLung injuryMajor complicationsAllogeneic recipientsBAL fluidLethal complicationPulmonary expression