2012
Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer
Meng L, Yang L, Zhao X, Zhang L, Zhu H, Liu C, Tan W. Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer. PLOS ONE 2012, 7: e33434. PMID: 22558072, PMCID: PMC3338807, DOI: 10.1371/journal.pone.0033434.Peer-Reviewed Original ResearchConceptsAptamer-drug conjugatesCancer-specific aptamersAntitumor agent doxorubicinDOX conjugatesIntercalation methodAptamerCell viability testTargeted deliveryConjugatesCancer cellsTarget proteinsAgent doxorubicinPotential candidateCell linesDOXEfficiency of chemotherapyLiver cancer cellsNonspecific uptakeTarget specificityAvailable aptamersCarcinoma cell linesChemotherapy agentsHepatocellular carcinoma cell linesHuman hepatocellular carcinoma cell linePromising method
2010
DNA Aptamers as Molecular Probes for Colorectal Cancer Study
Sefah K, Meng L, Lopez-Colon D, Jimenez E, Liu C, Tan W. DNA Aptamers as Molecular Probes for Colorectal Cancer Study. PLOS ONE 2010, 5: e14269. PMID: 21170319, PMCID: PMC3000811, DOI: 10.1371/journal.pone.0014269.Peer-Reviewed Original ResearchConceptsColorectal cancerAppropriate therapeutic regimensCell-based systematic evolutionColorectal Cancer StudyMolecular featuresMultistep carcinogenic processCancer cell linesCell line DLD-1Therapeutic regimensNormal colon cellsPrognostic markerDifferent tumorsSpecific tumorsFlow cytometrySpecific biomarkersEarly disease detectionCarcinogenic processTumorsCancerSpecific markersCancer studiesColon cellsDLD-1Cell linesDisease development