2014
Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip
Sheng W, Ogunwobi O, Chen T, Zhang J, George T, Liu C, Fan Z. Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip. Lab On A Chip 2014, 14: 89-98. PMID: 24220648, PMCID: PMC3918168, DOI: 10.1039/c3lc51017d.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ImmobilizedAntigens, NeoplasmAntineoplastic AgentsCell Adhesion MoleculesCell Line, TumorCell SeparationCell SurvivalEpithelial Cell Adhesion MoleculeHumansLeukocyte Common AntigensMaleMicrofluidic Analytical TechniquesNeoplastic Cells, CirculatingPancreatic NeoplasmsTomography, X-Ray ComputedConceptsHigh-performance microchipsMicromixer structurePresented technologyReal-time monitoringChannel geometryFlow rateTransverse flowCapture efficiencyChipDevicesCell capturePersonalized therapeutic treatmentsTumor cell captureAntibody-coated surfaceGreat promiseSpiked tumor cellsIsolation of CTCsWide rangeCancer patients' blood
2009
Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells
Cao M, Cabrera R, Xu Y, Liu C, Nelson D. Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells. Cell Biology International 2009, 33: 565-571. PMID: 19268553, PMCID: PMC2683182, DOI: 10.1016/j.cellbi.2009.02.007.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsSuppression of TregsT cell proliferationDose-dependent reductionTreg expressionTreg proliferationEffector cellsImmunologic balanceSuppressive capacityTregsGy/minDose gamma irradiationFlow cytometryThymidine incorporationUpregulated BaxCell proliferationCancer therapyHigh-dose gamma irradiationApoptosis inductionDifferent dosagesFunction changesGamma irradiationPhenotypeIrradiation alters