Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells
Cao M, Cabrera R, Xu Y, Liu C, Nelson D. Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells. Cell Biology International 2009, 33: 565-571. PMID: 19268553, PMCID: PMC2683182, DOI: 10.1016/j.cellbi.2009.02.007.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsSuppression of TregsT cell proliferationDose-dependent reductionTreg expressionTreg proliferationEffector cellsImmunologic balanceSuppressive capacityTregsGy/minDose gamma irradiationFlow cytometryThymidine incorporationUpregulated BaxCell proliferationCancer therapyHigh-dose gamma irradiationApoptosis inductionDifferent dosagesFunction changesGamma irradiationPhenotypeIrradiation alters