2020
Clinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase
Chien Y, Hwu H, Hwang T, Hsieh M, Liu C, Lin-Shiau S, Liu C. Clinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2020, 99: 109868. PMID: 31954755, DOI: 10.1016/j.pnpbp.2020.109868.Peer-Reviewed Original ResearchConceptsChronic stable schizophreniaNon-psychiatric controlsDisorganized symptomsChronic stable patientsStable schizophreniaWeeks of antipsychotic treatmentStages of schizophreniaAcute relapseClinical implicationsAntipsychotic treatmentNegative symptomsSchizophreniaStable patientsOxidative stressPlatelet superoxide dismutasePlatelet oxidative stressTreatment responseNitric oxideLipid peroxidationLevels of nitric oxideSymptomsSuperoxide dismutaseTreatment effectsRelapsed patientsRelapse
2016
Therapeutic improvements expected in the near future for schizophrenia and schizoaffective disorder: an appraisal of phase III clinical trials of schizophrenia-targeted therapies as found in US and EU clinical trial registries
Garay R, Citrome L, Samalin L, Liu C, Thomsen M, Correll C, Hameg A, Llorca P. Therapeutic improvements expected in the near future for schizophrenia and schizoaffective disorder: an appraisal of phase III clinical trials of schizophrenia-targeted therapies as found in US and EU clinical trial registries. Expert Opinion On Pharmacotherapy 2016, 17: 921-936. PMID: 26831200, DOI: 10.1517/14656566.2016.1149164.Peer-Reviewed Original ResearchConceptsCognitive impairment associated with schizophreniaSchizoaffective disorderNegative symptomsDopamine D2 receptor partial agonistTreatment of cognitive impairment associated with schizophreniaD2 receptor partial agonistTreating positive symptomsReceptor partial agonistEU clinical trial registriesAdd-on compoundsTardive dyskinesiaPositive symptomsGoal of recoverySchizophreniaPartial agonistAntipsychoticsSchizoaffectivePhase III of clinical developmentTherapeutic improvementDisordersClinical Trials RegistrySymptomsPharmacodynamic profileClinical developmentAcademic medical center
2013
Facial and Prosodic Emotion Recognition Deficits Associate with Specific Clusters of Psychotic Symptoms in Schizophrenia
Tseng H, Chen S, Liu C, Howes O, Huang Y, Hsieh M, Liu C, Shan J, Lin Y, Hwu H. Facial and Prosodic Emotion Recognition Deficits Associate with Specific Clusters of Psychotic Symptoms in Schizophrenia. PLOS ONE 2013, 8: e66571. PMID: 23818944, PMCID: PMC3688591, DOI: 10.1371/journal.pone.0066571.Peer-Reviewed Original ResearchConceptsEmotion recognition abilityCluster of psychotic symptomsPsychotic symptomsEmotion recognition taskHappy emotionHealthy participantsDysfunction of brain systemsSeverity of psychotic symptomsDeficits of emotion recognitionPresentation of psychotic symptomsDSM-IV diagnostic criteriaRecognition taskPANSS total scoreSensory modalitiesEmotion recognitionRecognition abilityEvaluation of symptomatologySeverity of clinical symptomsHappy prosodyNegative symptomsPerseveration errorsWAIS-IIIDSM-IVEmotional processingBrain systems
2011
Autonomic Modulation and Health-Related Quality of Life among Schizophrenic Patients Treated with Non-Intensive Case Management
Chang L, Lin Y, Kuo T, Chang H, Liu C, Liu C, Hwu H, Yang C. Autonomic Modulation and Health-Related Quality of Life among Schizophrenic Patients Treated with Non-Intensive Case Management. PLOS ONE 2011, 6: e26378. PMID: 22073161, PMCID: PMC3208549, DOI: 10.1371/journal.pone.0026378.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome Scale for SchizophreniaSchizophrenic patientsNegative symptomsAssociated with more negative symptomsNon-ICMHealth-related quality of lifeSchizophreniaAutonomic modulationHealth-related qualityAnticholinergic useQuality of lifeAssociated with autonomic dysfunctionHigher VAS scoreCommunity settingsIncreased cardiovascular mortalityEQ-5DBody mass indexClinical variablesVisual analogue scaleEQ-VASSymptomsImpairmentHeart rate variability measuresCardiovagal dysfunctionScores
2010
Patient subgroups of schizophrenia based on the Positive and Negative Syndrome Scale: composition and transition between acute and subsided disease states
Huang G, Tsai H, Hwu H, Chen C, Liu C, Hua M, Chen W. Patient subgroups of schizophrenia based on the Positive and Negative Syndrome Scale: composition and transition between acute and subsided disease states. Comprehensive Psychiatry 2010, 52: 469-478. PMID: 21193177, DOI: 10.1016/j.comppsych.2010.10.012.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScaleNegative Syndrome ScaleNegative symptomsSyndrome ScaleWhole syndromeFlorid symptomsNeurobiological studies of schizophreniaPartial syndromesSubgroup of schizophreniaStudies of schizophreniaReality distortionAcute schizophreniaNeurocognitive variablesLatent class analysisNeurobiological studiesSchizophreniaSymptom patternsPatient subgroupsAcute stateClass analysisSociodemographic variablesPAN dataSymptomsHostilityRegression extensionFollow-up of subjects with suspected pre-psychotic state in Taiwan
Liu C, Lai M, Liu C, Chiu Y, Hsieh M, Hwang T, Chien Y, Chen W, Hua M, Hsiung P, Huang Y, Hwu H. Follow-up of subjects with suspected pre-psychotic state in Taiwan. Schizophrenia Research 2010, 126: 65-70. PMID: 21112187, DOI: 10.1016/j.schres.2010.10.028.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisPre-psychotic stateUHR subjectsRate of conversion to psychosisUltra-high-risk groupConversion to psychosisPsychosis risk syndromeFollow-upRisk groupsIntermediate-risk groupNegative symptomsSchizophreniform disorderSchizoaffective disorderPsychotic disordersAntipsychotic useBipolar disorderClinical interviewFollow-up of subjectsOutcomes of subjectsCommunity-based populationRisk syndromeDiagnostic categoriesPsychosisClinical attentionUHR