2014
Epigenetic regulation of OPA1 sensitizes hepatocellular carcinoma to sorafenib‐induced apoptosis (59.1)
Puszyk W, Dong H, Zhao F, Shisgal P, Cabrera R, Neslon D, Liu C. Epigenetic regulation of OPA1 sensitizes hepatocellular carcinoma to sorafenib‐induced apoptosis (59.1). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.59.1.Peer-Reviewed Original ResearchDNA methylationHepatocellular carcinomaEpigenetic regulationProtein OPA1HCC cellsMitochondrial fragmentationGene promoterC releaseEpigenetic analysisXenograft tumor growthEpigenetic markersSorafenib-induced apoptosisAkt pathwayOPA1HCC xenograft tumor growthHepatocellular carcinoma cellsNovel therapeutic targetExpression levelsTumorigenesis of HCCIdentification of patientsPathogenesis of HCCOPA1 knockdownApoptosisPrimary hepatocytesSensitivity of HCC
2011
Epigenetic regulation of homeobox genes in liver cancer
Liu H, Robertson K, Liu C. Epigenetic regulation of homeobox genes in liver cancer. The FASEB Journal 2011, 25: 794.12-794.12. DOI: 10.1096/fasebj.25.1_supplement.794.12.Peer-Reviewed Original ResearchHox genesEpigenetic regulationHomeobox genesAmino acid DNA-binding domainHox gene regulationDNA-binding domainHox gene familyHCC cell linesBp DNA sequenceCell linesGene familyGene regulationEpigenetic modificationsEpigenetic mechanismsIdentity of cellsTranscription factorsDNA sequencesTrichostatin A.Expression profilesCancer tissuesDifferential expressionGenesCell line experimentsNormal developmentHCC cancer tissues