TRAIL/ DR5 Interactions Are Important for Thymic Damage After Allogeneic Bone Marrow Transplantation.
Na I, Lu S, Yim N, Goldberg G, Tsai J, Rao U, Smith O, King C, Suh D, Hirschhorn-Cymerman D, Palomba M, Penack O, Holland A, Jenq R, Ghosh A, Tran H, Merghoub T, Liu C, Sempowski G, Ventevogel M, Beauchemin N, Furie B, van den Brink M. TRAIL/ DR5 Interactions Are Important for Thymic Damage After Allogeneic Bone Marrow Transplantation. Blood 2009, 114: 234. DOI: 10.1182/blood.v114.22.234.234.Peer-Reviewed Original ResearchAlloreactive T cellsDonor alloreactive T cellsAllogeneic bone marrow transplantationT-cell dosePost-transplant periodBone marrow transplantationAllo-BMTT cellsThymic damageThymic cellularityMarrow transplantationCell doseThymic stromaDay 28Early post-transplant periodAllo-BMT recipientsPeri-transplant periodDonor T cellsFas/Fas ligandOvert clinical diseaseSignificant weight lossExpression of DR5TRAIL/DR5 pathwayRole of TRAILAnti-apoptotic protein cFLIP