Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits
Liu Y, Wang S, Hwu H, Fann C, Yang U, Yang W, Hsu P, Chang C, Wen C, Tsai-Wu J, Hwang T, Hsieh M, Liu C, Chien Y, Fang C, Faraone S, Tsuang M, Chen W, Liu C. Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits. PLOS ONE 2016, 11: e0150435. PMID: 26986737, PMCID: PMC4795637, DOI: 10.1371/journal.pone.0150435.Peer-Reviewed Original ResearchConceptsSingle-nucleotide polymorphismsAssociated with schizophreniaIntron 8Genomic regionsIntron 1Genetic variantsLarger patient samplesD-amino-acid oxidase geneNovel single‐nucleotide polymorphismsHaplotype association analysisSingle-locus analysisExecutive functionD-amino acid oxidaseFunctional genetic variantsSustained attentionNeurocognitive functionSchizophreniaEpstein-Barr virus-transformed lymphocytesMRNA expressionHaplotype blocksSingle-locusHaplotype distributionVirus-transformed lymphocytesHaplotype frequenciesAssociation analysis