2016
Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue
Lai C, Lee S, Scarr E, Yu Y, Lin Y, Liu C, Hwang T, Hsieh M, Liu C, Chien Y, Udawela M, Gibbons A, Everall I, Hwu H, Dean B, Chen W. Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue. Translational Psychiatry 2016, 6: e717-e717. PMID: 26784971, PMCID: PMC5068884, DOI: 10.1038/tp.2015.213.Peer-Reviewed Original ResearchConceptsPeripheral miRNAsState-dependent markersDiagnostic of schizophreniaHsa-miR-34aPostmortem brain tissueAberrant expression of microRNAsCaudate putamenSchizophreniaSubcortical regionsAcute stateExpression of microRNAsSeven-miRNARemission stateBrain samplesAberrant expressionClinically useful biomarkersExpression levelsBrainMonths of hospitalizationPartial remission stateAge-dependent increaseMiRNA dysregulationMiRNAsPartial remissionClinical symptoms
2010
Patient subgroups of schizophrenia based on the Positive and Negative Syndrome Scale: composition and transition between acute and subsided disease states
Huang G, Tsai H, Hwu H, Chen C, Liu C, Hua M, Chen W. Patient subgroups of schizophrenia based on the Positive and Negative Syndrome Scale: composition and transition between acute and subsided disease states. Comprehensive Psychiatry 2010, 52: 469-478. PMID: 21193177, DOI: 10.1016/j.comppsych.2010.10.012.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScaleNegative Syndrome ScaleNegative symptomsSyndrome ScaleWhole syndromeFlorid symptomsNeurobiological studies of schizophreniaPartial syndromesSubgroup of schizophreniaStudies of schizophreniaReality distortionAcute schizophreniaNeurocognitive variablesLatent class analysisNeurobiological studiesSchizophreniaSymptom patternsPatient subgroupsAcute stateClass analysisSociodemographic variablesPAN dataSymptomsHostilityRegression extension