2018
A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D
Belsky JB, Wira CR, Jacob V, Sather JE, Lee PJ. A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. Nutrition Research Reviews 2018, 31: 281-290. PMID: 29984680, DOI: 10.1017/s0954422418000124.Peer-Reviewed Original ResearchConceptsVitamin CLife-threatening organ dysfunctionRole of micronutrientsCurrent available dataSeptic patientsOrgan dysfunctionSeptic shockVitamin DVitamin D.Clinical trialsRole of thiamineThiamine deficiencySepsisHuman studiesHost responseConclusion statementsCellular dysfunctionNormal physiologyMetabolic demandsCarnitinePotential roleDysfunctionPresent reviewCellular turnoverPivotal role
2015
Lactate Clearance Predicts Survival Among Patients in the Emergency Department with Severe Sepsis
Bhat SR, Swenson KE, Francis MW, Wira CR. Lactate Clearance Predicts Survival Among Patients in the Emergency Department with Severe Sepsis. Western Journal Of Emergency Medicine 2015, 16: 1118-1126. PMID: 26759665, PMCID: PMC4703153, DOI: 10.5811/westjem.2015.10.27577.Peer-Reviewed Original ResearchConceptsSevere sepsisSeptic shockLactate clearanceClearance groupLactate levelsPredictors of mortalityEmergency department patientsInitial lactate levelCross-sectional studySepsis registryVasopressor supportED stayDepartment patientsHospital interventionsMechanical ventilationEmergency departmentLactate changesSepsisPatientsMortality rateHigh mortalityHospital floorMortalityClearanceEDGoal-Directed Therapy for Sepsis: Has the Beast Been Slain or Do Questions Remain?
Wira CR, Swenson K. Goal-Directed Therapy for Sepsis: Has the Beast Been Slain or Do Questions Remain? Connecticut Medicine 2015, 79: 97-9. PMID: 26244208.Peer-Reviewed Original Research
2014
Early Identification and Management of Patients with Severe Sepsis and Septic Shock in the Emergency Department
Keegan J, Wira CR. Early Identification and Management of Patients with Severe Sepsis and Septic Shock in the Emergency Department. Emergency Medicine Clinics Of North America 2014, 32: 759-776. PMID: 25441033, DOI: 10.1016/j.emc.2014.07.002.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsEmergency Service, HospitalHumansRisk AssessmentSepsisShock, SepticVasoconstrictor AgentsMeta-analysis of Protocolized Goal-Directed Hemodynamic Optimization for the Management of Severe Sepsis and Septic Shock in the Emergency Department
Wira CR, Dodge K, Sather J, Dziura J. Meta-analysis of Protocolized Goal-Directed Hemodynamic Optimization for the Management of Severe Sepsis and Septic Shock in the Emergency Department. Western Journal Of Emergency Medicine 2014, 15: 51-59. PMID: 24696750, PMCID: PMC3952890, DOI: 10.5811/westjem.2013.7.6828.Peer-Reviewed Original Research
2011
Etomidate use in severe sepsis and septic shock patients does not contribute to mortality
Ehrman R, Wira C, Lomax A, Hayward A, Marcelin J, Ellis T, Przyklenk K, Volturo G, Mullen M. Etomidate use in severe sepsis and septic shock patients does not contribute to mortality. Internal And Emergency Medicine 2011, 6: 253-257. PMID: 21394520, DOI: 10.1007/s11739-011-0553-3.Peer-Reviewed Original ResearchConceptsUse of etomidateSeptic shock patientsSevere sepsisEtomidate useShock patientsSeptic shockEtomidate groupSevere sepsis/septic shock patientsSepsis/septic shock patientsUniversity tertiary care referral centerIntensive care unit lengthRetrospective multi-center studyTertiary care referral centerMechanical ventilation daysAPACHE II scoreUse of corticosteroidsRetrospective chart reviewMulti-center studyHospital mortalityII scorePrimary endpointVentilation daysAdrenal insufficiencyChart reviewPatient demographics