2023
Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis
Ozmen A, Nwabuobi C, Tang Z, Guo X, Larsen K, Guller S, Blas J, Moore M, Kayisli U, Lockwood C, Guzeloglu-Kayisli O. Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis. International Journal Of Molecular Sciences 2023, 25: 135. PMID: 38203306, PMCID: PMC10778808, DOI: 10.3390/ijms25010135.Peer-Reviewed Original ResearchConceptsIL-6 expressionHofbauer cellsP65 NF-κBIL-6NF-κBLeptin levelsPreeclampsia pathogenesisElevated serum interleukin-6 levelsSerum interleukin-6 levelsERK1/2 MAPKInterleukin-6 levelsPro-inflammatory phenotypeAnti-inflammatory phenotypeLeptin receptor expressionIL-6 productionPathogenesis of PEPlacental leptin productionPhosphorylation levelsERK1/2 MAPK inhibitorIL-6 regulationConcentration-dependent mannerPE patientsHuman pregnancySecond trimesterLeptin concentrations
2008
Decidual Cell‐expressed Tissue Factor in Human Pregnancy and Its Involvement in Hemostasis and Preeclampsia‐related Angiogenesis
Lockwood CJ, Krikun G, Caze R, Rahman M, Buchwalder LF, Schatz F. Decidual Cell‐expressed Tissue Factor in Human Pregnancy and Its Involvement in Hemostasis and Preeclampsia‐related Angiogenesis. Annals Of The New York Academy Of Sciences 2008, 1127: 67-72. PMID: 18443332, DOI: 10.1196/annals.1434.013.Peer-Reviewed Original ResearchConceptsDecidual cell-expressed tissue factorUteroplacental blood flowVascular endothelial growth factorTissue factorDecidual cellsBlood flowFirst trimester decidual cellsGrowth factorPlacental growth factorProtease-activated receptorsSFlt-1 expressionEndothelial growth factorPredominant cell typeMaternal thrombophiliaMaternal morbidityDecidual hemorrhageSpiral arteriesHuman pregnancySFlt-1Trophoblast invasionVascular remodelingPreeclampsiaVEGF expressionExcess thrombinAngiogenic effects
1994
Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta
Guller S, Markiewicz L, Wozniak R, Burnham J, Wang E, Kaplan P, Lockwood C. Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta. Endocrinology 1994, 134: 2064-2071. DOI: 10.1210/en.134.5.2064.Peer-Reviewed Original ResearchEffects of glucocorticoidsTerm cellsLevels of glucocorticoidsTrimester cellsDexamethasone treatmentTrimester of human pregnancyControl levelsGlucocorticoid responseSeparation of placentaTreatment of cytotrophoblastsLevels of hCGControl valuesIncreased glucocorticoid responseHuman first trimesterLow levels of glucocorticoidsGlucocorticoid-mediated effectsLevels of FN mRNARates of FNElevated levels of glucocorticoidsExtracellular matrix protein expressionLevels of FNCytotrophoblast culturesReduced glucocorticoid responsivenessHuman pregnancyFirst-trimester