2023
Distinguishing features of long COVID identified through immune profiling
Klein J, Wood J, Jaycox J, Dhodapkar R, Lu P, Gehlhausen J, Tabachnikova A, Greene K, Tabacof L, Malik A, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, Ott I, Valle G, Peña-Hernández M, Mao T, Bhattacharjee B, Takahashi T, Lucas C, Song E, McCarthy D, Breyman E, Tosto-Mancuso J, Dai Y, Perotti E, Akduman K, Tzeng T, Xu L, Geraghty A, Monje M, Yildirim I, Shon J, Medzhitov R, Lutchmansingh D, Possick J, Kaminski N, Omer S, Krumholz H, Guan L, Dela Cruz C, van Dijk D, Ring A, Putrino D, Iwasaki A. Distinguishing features of long COVID identified through immune profiling. Nature 2023, 623: 139-148. PMID: 37748514, PMCID: PMC10620090, DOI: 10.1038/s41586-023-06651-y.Peer-Reviewed Original ResearchConceptsLong COVIDSARS-CoV-2Infection syndromeExaggerated humoral responseSoluble immune mediatorsEpstein-Barr virusPost-exertional malaiseCross-sectional studyHigher antibody responseImmune mediatorsImmune phenotypingImmune profilingHumoral responseAntibody responseLymphocyte populationsCOVID statusUnbiased machineCortisol levelsLC statusRelevant biomarkersViral pathogensSyndromeCOVIDFuture studiesBiological features
2009
Complex N-Linked Glycans on Asn-89 of Kaposi Sarcoma Herpes Virus-encoded Interleukin-6 Mediate Optimal Function by Affecting Cytokine Protein Conformation*
Dela Cruz CS, Viswanathan SR, El-Guindy AS, Shedd D, Miller G. Complex N-Linked Glycans on Asn-89 of Kaposi Sarcoma Herpes Virus-encoded Interleukin-6 Mediate Optimal Function by Affecting Cytokine Protein Conformation*. Journal Of Biological Chemistry 2009, 284: 29269-29282. PMID: 19690161, PMCID: PMC2785557, DOI: 10.1074/jbc.m109.039115.Peer-Reviewed Original ResearchConceptsVIL-6IL-6RalphaProtein conformationComplex glycansHuman cellular homologueSimilar biological functionsKaposi's sarcoma-associated herpesvirusAsn-89Conformation-specific antibodiesCellular homologueCytokine functionSarcoma-associated herpesvirusProtein functionHigh-mannose glycansBiological functionsViral cytokineDigestion assaysMannose glycansGp130Optimal functionGlycansGlycosylationHuman IL-6HuIL-6Intracellular production