2012
Chitinase 3-like-1 Promotes Streptococcus pneumoniae Killing and Augments Host Tolerance to Lung Antibacterial Responses
Dela Cruz CS, Liu W, He CH, Jacoby A, Gornitzky A, Ma B, Flavell R, Lee CG, Elias JA. Chitinase 3-like-1 Promotes Streptococcus pneumoniae Killing and Augments Host Tolerance to Lung Antibacterial Responses. Cell Host & Microbe 2012, 12: 34-46. PMID: 22817986, PMCID: PMC3613130, DOI: 10.1016/j.chom.2012.05.017.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCarrier ProteinsCaspase 1Cell DeathChitinase-3-Like Protein 1CytokinesGlycoproteinsHost-Pathogen InteractionsInflammasomesLungMacrophagesMiceMice, Mutant StrainsNLR Family, Pyrin Domain-Containing 3 ProteinPhagocytosisPneumococcal InfectionsPneumonia, PneumococcalReceptors, Purinergic P2X7Streptococcus pneumoniaeConceptsHost toleranceAntibacterial responseChitinase-like proteinsEvolutionary timeHost antibacterial responsesATP accumulationChitinase 3Bacterial clearanceCentral roleMacrophage pyroptosisToleranceBacterial disseminationInflammasome activationStreptococcus pneumoniaeBacterial killingType 17 cytokinesThymic stromal lymphopoietinCHI3L1SpeciesProteinBacteriaLung injuryHostRolePyroptosis
2011
Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury
Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA. Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury. Annual Review Of Physiology 2011, 73: 479-501. PMID: 21054166, PMCID: PMC3864643, DOI: 10.1146/annurev-physiol-012110-142250.Peer-Reviewed Original ResearchConceptsBRP-39/YKLAdaptive Th2 immunityTissue remodelingChitinase-like proteinsAlternative macrophage activationTh2 inflammationInnate inflammationLung injuryTh2 immunityAcidic mammalian chitinaseAncient gene familyIL-13YKL-40Tissue injuryNumber of chitinasesEffector functionsMacrophage activationFamily of chitinasesInflammationDisease severityInjuryRole of chitinMammalian chitinaseGene familyEndogenous chitin
2010
Role of Breast Regression Protein–39 in the Pathogenesis of Cigarette Smoke–Induced Inflammation and Emphysema
Matsuura H, Hartl D, Kang MJ, Dela Cruz CS, Koller B, Chupp GL, Homer RJ, Zhou Y, Cho WK, Elias JA, Lee CG. Role of Breast Regression Protein–39 in the Pathogenesis of Cigarette Smoke–Induced Inflammation and Emphysema. American Journal Of Respiratory Cell And Molecular Biology 2010, 44: 777-786. PMID: 20656949, PMCID: PMC3135840, DOI: 10.1165/rcmb.2010-0081oc.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseBRP-39/YKLBreast regression protein 39YKL-40BRP-39Alveolar destructionCigarette smokeChitinase-like protein YKL-40Emphysematous alveolar destructionLungs of CSObstructive pulmonary diseaseProtein YKL-40Excessive inflammatory responseAirway epithelial cellsAlveolar type II cellsNull mutant miceProtein 39Epithelial cell apoptosisType II cellsCurrent smokersPulmonary diseaseBronchoalveolar lavageTissue inflammationEmphysematous destructionSerum concentrations