2015
Regulation of Retinoic Acid Receptor Beta by Interleukin-15 in the Lung during Cigarette Smoking and Influenza Virus Infection
Wang J, Liu W, Marion C, Singh R, Andrews N, Lee CG, Elias JA, Dela Cruz CS. Regulation of Retinoic Acid Receptor Beta by Interleukin-15 in the Lung during Cigarette Smoking and Influenza Virus Infection. American Journal Of Respiratory Cell And Molecular Biology 2015, 53: 822-833. PMID: 25923039, PMCID: PMC4742936, DOI: 10.1165/rcmb.2014-0448oc.Peer-Reviewed Original ResearchConceptsInfluenza virus infectionCS exposureVirus infectionIL-15WT miceIL-15 knockout miceIL-15 receptor αIL-15 transgenic miceLong-term CS exposureChronic obstructive pulmonary diseaseIL-15tg miceLung interstitial macrophagesCigarette smoke exposureVirus-induced exacerbationsObstructive pulmonary diseaseAntiviral immune responseWild-type miceRetinoic acid receptor betaRA receptor βAcid receptor betaLung injuryLung functionPulmonary diseaseRARβ expressionSmoke exposure
2004
N-linked Glycosylation Is Required for Optimal Function of Kaposi's Sarcoma Herpesvirus–encoded, but Not Cellular, Interleukin 6
Dela Cruz CS, Lee Y, Viswanathan SR, El-Guindy AS, Gerlach J, Nikiforow S, Shedd D, Gradoville L, Miller G. N-linked Glycosylation Is Required for Optimal Function of Kaposi's Sarcoma Herpesvirus–encoded, but Not Cellular, Interleukin 6. Journal Of Experimental Medicine 2004, 199: 503-514. PMID: 14970177, PMCID: PMC2211829, DOI: 10.1084/jem.20031205.Peer-Reviewed Original ResearchConceptsVIL-6Janus tyrosine kinaseSimilar biological functionsActivator of transcriptionGp130 receptor subunitCellular IL-6Distinct functional rolesFunctional homologueBiological functionsSignal transducerTyrosine kinaseFunctional roleKaposi's sarcoma herpesvirusCell proliferation bioassayGlycosylationCell proliferationReceptor subunitsGp130B cell proliferationN89PathwayOptimal functionTranscriptionHomologuesKinase