Featured Publications
Racial and ethnic differences in alcohol, cannabis, and illicit substance use treatment: a systematic review and narrative synthesis of studies done in the USA
Jordan A, Quainoo S, Nich C, Babuscio TA, Funaro MC, Carroll KM. Racial and ethnic differences in alcohol, cannabis, and illicit substance use treatment: a systematic review and narrative synthesis of studies done in the USA. The Lancet Psychiatry 2022, 9: 660-675. PMID: 35752192, DOI: 10.1016/s2215-0366(22)00160-2.Peer-Reviewed Original ResearchConceptsSubstance use outcomesTreatment initiationJoanna Briggs Institute appraisal toolsSystematic reviewSubstance use disordersSignificant differencesSubstance use treatmentDissemination of treatmentUncontrolled trialsClinical trialsBaseline differencesStudy qualityInclusion criteriaUse disordersRCTsNarrative synthesisSocial determinantsUse treatmentAppraisal toolLatinx adultsEthnic differencesEthnic populationsOutcomesTrialsLatinx populations
2024
Improvement in coping skills from culturally-adapted digital CBT for Spanish-speaking Hispanics with substance use disorder: Secondary analysis of a randomized clinical trial
Benitez B, Loya J, Jaramillo Y, Muro-Rodriguez N, Rojas Perez O, Nich C, Frankforter T, Paris M, Kiluk B. Improvement in coping skills from culturally-adapted digital CBT for Spanish-speaking Hispanics with substance use disorder: Secondary analysis of a randomized clinical trial. Journal Of Substance Use And Addiction Treatment 2024, 168: 209536. PMID: 39374899, DOI: 10.1016/j.josat.2024.209536.Peer-Reviewed Original ResearchMechanisms of cognitive behavioral therapyQuality of coping skillsCognitive behavioral therapySubstance use disordersPrimary substance useCoping skillsSubstance useCBT programOutpatient treatmentWeeks of outpatient treatmentDigital cognitive behavioral therapyMechanisms of behavior changeWithin-person increasesDaily substance useAdaptive coping skillsSecondary analysis of clinical trial dataTreatment mechanismsRandomized to 8Associated with reductionsBehavioral therapyAnalysis of clinical trial dataUse disorderGeneralizability of researchSecondary analysisSpanish-speaking Hispanic adultsA Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder
Kiluk B, Benitez B, DeVito E, Frankforter T, LaPaglia D, O’Malley S, Nich C. A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder. JAMA Network Open 2024, 7: e2435205. PMID: 39325452, PMCID: PMC11428014, DOI: 10.1001/jamanetworkopen.2024.35205.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDigital cognitive behavioral therapyAlcohol use disorderAlcohol useCBT programUse disorderCognitive behavioral therapy programCurrent alcohol use disorderTreatment-seeking adultsBehavioral therapy programEvidence-based treatmentsBaseline to 6-month follow-upRates of alcohol useReducing alcohol useTreatment periodRandomized clinical trialsBehavioral therapyOutpatient substancePercentage of daysOutpatient treatmentIntention-to-treat analysisIndividual counselingStudy periodFollow-upIntention-to-treatMeasurement invariance of the Perceived Stress Scale across race, sex, and time, and differential impacts on cocaine use treatment outcomes
Schick M, Kiluk B, Nich C, LaPaglia D, Haeny A. Measurement invariance of the Perceived Stress Scale across race, sex, and time, and differential impacts on cocaine use treatment outcomes. Journal Of Substance Use And Addiction Treatment 2024, 166: 209493. PMID: 39151798, PMCID: PMC11392621, DOI: 10.1016/j.josat.2024.209493.Peer-Reviewed Original ResearchCocaine use disorderPerceived Stress ScaleTreatment retentionMeasurement invarianceTreatment outcomesSubstance use treatment outcomesStress ScalePredicting treatment retentionSelf-efficacyCoping self-efficacyTwo-factor modelInfluence treatment outcomeCocaine abuse/dependenceDSM-IVUse disorderCocaine useBetween-group differencesMetric invarianceScalar invarianceTwo-factorCocainePharmacological treatmentFactor analysisDifferential impactAbuse/dependenceT166 Treatment Outcomes From Computerized CBT for Substance Use Disorders Among People With Criminal Justice Involvement
Loya J, Babuscio T, Nich C, Kiluk B. T166 Treatment Outcomes From Computerized CBT for Substance Use Disorders Among People With Criminal Justice Involvement. Drug And Alcohol Dependence 2024, 260: 110615. DOI: 10.1016/j.drugalcdep.2023.110615.Peer-Reviewed Original ResearchStructural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment
McCurdy L, DeVito E, Loya J, Nich C, Zhai Z, Kiluk B, Potenza M. Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment. Drug And Alcohol Dependence Reports 2024, 11: 100246. PMID: 38966567, PMCID: PMC11222934, DOI: 10.1016/j.dadr.2024.100246.Peer-Reviewed Original ResearchCocaine use disorderCognitive behavioral therapyCocaine useBehavioral therapyBrain changesBrain structuresWhole-brain voxel-based morphometry analysisCocaine use disorder treatmentLevel of cocaine useWeeks of outpatient treatmentVoxel-based morphometry analysisDigital cognitive behavioral therapyT1-weighted magnetic resonance imaging scansRight caudate bodyAssociated with cocaine useMethadone-maintained individualsGray matter volumeStructural brain changesFunction of engagementCaudate bodyRight caudateCUD treatmentMatter volumeUse disorderBilateral cerebellumCognitive processing therapy (CPT) versus individual drug counseling (IDC) for PTSD for veterans with opioid use disorder maintained on buprenorphine
Petrakis I, Meshberg‐Cohen S, Nich C, Kelly M, Claudio T, Jane J, Pisani E, Ralevski E. Cognitive processing therapy (CPT) versus individual drug counseling (IDC) for PTSD for veterans with opioid use disorder maintained on buprenorphine. American Journal On Addictions 2024, 33: 525-533. PMID: 38624259, DOI: 10.1111/ajad.13557.Peer-Reviewed Original ResearchCognitive processing therapyIndividual drug counselingPosttraumatic stress disorderOpioid use disorderSubstance use disordersDrug counselingProcessing therapyPTSD symptomsUse disorderCognitive processing therapy groupEvidence-based trauma-focused psychotherapiesSelf-reported PTSD symptomsPosttraumatic stress disorder symptomsPosttraumatic stress disorder treatmentRemission of PTSD symptomsPosttraumatic Stress Disorder ChecklistComorbid opioid use disorderTrauma-focused psychotherapyTrauma-focused treatmentRates of comorbidityTreatment group differencesPCL-5Stress disorderGroup differencesRandomized clinical trialsEfficacy of Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) in Individuals With Chronic Pain and Opioid Use Disorder: Protocol for a Randomized Clinical Trial of a Digital Cognitive Behavioral Treatment
MacLean R, Ankawi B, Driscoll M, Gordon M, Frankforter T, Nich C, Szollosy S, Loya J, Brito L, Ribeiro M, Edmond S, Becker W, Martino S, Sofuoglu M, Heapy A. Efficacy of Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) in Individuals With Chronic Pain and Opioid Use Disorder: Protocol for a Randomized Clinical Trial of a Digital Cognitive Behavioral Treatment. JMIR Research Protocols 2024, 13: e54342. PMID: 38506917, PMCID: PMC10993119, DOI: 10.2196/54342.Peer-Reviewed Original Research
2023
The connection still matters: Therapeutic alliance with digital treatment for alcohol use disorder
Benitez B, Frankforter T, Nich C, Kiluk B. The connection still matters: Therapeutic alliance with digital treatment for alcohol use disorder. Alcohol Clinical And Experimental Research 2023, 47: 2197-2207. PMID: 38226756, PMCID: PMC10792249, DOI: 10.1111/acer.15199.Peer-Reviewed Original ResearchWorking Alliance InventoryAlliance ratingsAlcohol useMinimal clinical monitoringOutpatient AUD treatmentPatient-reported measuresAlcohol use disorderDisorder treatment outcomesDaily alcohol useCognitive behavioral therapy programBehavioral therapy programAlcohol use disorder treatment outcomesClinical trialsTreatment outcomesFuture drinkingUse disordersTreatment efficacyTreatment sessionsAUD treatmentClinical monitoringComputerized cognitive behavioural therapy programmeTherapy programFuture alcohol useTherapeutic allianceAlliance InventoryPercentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use
Loya J, Babuscio T, Nich C, Alessi S, Rash C, Kiluk B. Percentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use. Drug And Alcohol Dependence 2023, 248: 109947. PMID: 37276806, PMCID: PMC10498479, DOI: 10.1016/j.drugalcdep.2023.109947.Peer-Reviewed Original ResearchConceptsUrine drug screensClinical trialsMeaningful endpointsCocaine useLong-term clinical benefitBetter long-term outcomesDrug screensPsychosocial functioningNegative urine drug screensLong-term outcomesRandomized clinical trialsFuture clinical trialsBetter psychosocial functioningClinical benefitPharmacological treatmentContinuous abstinenceTreatment periodTreatment respondersSustained abstinenceSubstance useTrialsTreatmentMeaningful thresholdPooled datasetAbstinenceBreaking through social determinants of health: Results from a feasibility study of Imani Breakthrough, a community developed substance use intervention for Black and Latinx people
Jordan A, Costa M, Nich C, Swarbrick M, Babuscio T, Wyatt J, O'Connell M, Guy K, Blackman K, Anderson R, Reis G, Ocasio L, Crespo M, Bellamy C. Breaking through social determinants of health: Results from a feasibility study of Imani Breakthrough, a community developed substance use intervention for Black and Latinx people. Journal Of Substance Use And Addiction Treatment 2023, 153: 209057. PMID: 37207836, DOI: 10.1016/j.josat.2023.209057.Peer-Reviewed Original ResearchConceptsSocial determinantsMental Health Services AdministrationDimensions of wellnessCommunity-based participatory research approachRate of deathHealth Services AdministrationDrug overdose ratesSubset of participantsSubstance use interventionsWeek 12Opioid overdoseOverdose ratesSubstance misuseEthnic disparitiesDisparity gapParticipatory research approachAddiction servicesSubstance abuseWeeks of educationHealth equityMental healthSubstance useLatinx peopleIntervention programsServices AdministrationThe Rise and Fall of Substance Use During Treatment: Applying Recency and Expectancy Principles to Daily Substance Use Patterns
Benitez B, Frankforter T, Nich C, Kiluk BD. The Rise and Fall of Substance Use During Treatment: Applying Recency and Expectancy Principles to Daily Substance Use Patterns. Psychology Of Addictive Behaviors 2023, 37: 235-246. PMID: 35201805, PMCID: PMC9399316, DOI: 10.1037/adb0000824.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapySubstance use disordersSubstance use patternsSubstance useTherapy sessionsRandomized clinical trial dataComputerized cognitive behavioral therapyClinical trial dataOutpatient SUD treatmentNext therapy sessionClinical trialsTherapy daysTreatment mechanismsSUD treatmentUse disordersTreatment efficacyTreatment sessionsTherapeutic contactDaily substance useTrial dataSecondary analysisSUD severityBehavioral therapyDrug typeWeekly proportionPromoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population
Edelman E, Rojas-Perez O, Nich C, Corvino J, Frankforter T, Gordon D, Jordan A, Paris, Jr M, Weimer M, Yates B, Williams E, Kiluk B. Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population. Addiction Science & Clinical Practice 2023, 18: 55. PMID: 37726823, PMCID: PMC10510167, DOI: 10.1186/s13722-023-00407-9.Peer-Reviewed Original ResearchConceptsPost-hospital dischargeCognitive behavioral therapySelf-reported alcohol useBrief Negotiation InterviewUse disordersAlcohol use outcomesComputer-based trainingDays post-hospital dischargeAlcohol use disorderBehavioral therapyInitiation of medicationHealth care utilizationHealth promotion advocatesTreatment engagementUse outcomesAlcohol useSecondary outcomesHospitalized patientsPrimary outcomeCare utilizationClinical trialsAcademic hospitalExploratory outcomesAUDProcess evaluation
2022
Modafinil does not reduce cocaine use in methadone-maintained individuals
DeVito EE, Poling J, Babuscio T, Nich C, Carroll KM, Sofuoglu M. Modafinil does not reduce cocaine use in methadone-maintained individuals. Drug And Alcohol Dependence Reports 2022, 2: 100032. PMID: 36310662, PMCID: PMC9615926, DOI: 10.1016/j.dadr.2022.100032.Peer-Reviewed Original ResearchCocaine use disorderCocaine use outcomesOpioid useCognitive behavioral therapyContingency managementCocaine dependenceCognitive functionMethadone-maintained individualsUse outcomesEfficacy of modafinilSelf-reported abstinenceTreatment of CUDStimulant-like effectsPlatform treatmentPercentage of urinesPercent of daysDual opioidModafinil treatmentUse disordersPotential efficacyCocaine useModafinilPlaceboMinimal reportsBehavioral therapy
2021
Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory
Kiluk BD, Roos CR, Aslan M, Gueorguieva R, Nich C, Babuscio TA, Carroll KM. Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory. Drug And Alcohol Dependence 2021, 228: 109070. PMID: 34600247, PMCID: PMC8595796, DOI: 10.1016/j.drugalcdep.2021.109070.Peer-Reviewed Original ResearchConceptsAddiction Severity IndexGlobal Severity IndexPsychiatric composite scoreClinical trialsCocaine useCocaine use disorderPsychiatric functioningBrief Symptom InventorySeverity IndexUse disordersASI psychiatric composite scoreSymptom InventoryEffect sizeStart of treatmentComposite scoreClinical trial participantsWeek 12Functional outcomeTreatment periodTrial participantsPsychiatric problemsDrug usePotential functional benefitsMedium effect sizeSubstance usersA pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy
Kacmarek CN, Yates BT, Nich C, Kiluk BD. A pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy. Alcohol Clinical And Experimental Research 2021, 45: 1109-1121. PMID: 33730384, PMCID: PMC8131237, DOI: 10.1111/acer.14601.Peer-Reviewed Original ResearchConceptsAlcohol use disorderIncremental cost-effective ratioCognitive behavioral therapyStandard outpatient treatmentPilot economic evaluationOutpatient treatmentTreatment costsUse disordersDrinking daysBehavioral therapyComputerized cognitive behavioral therapyEvidence-based treatmentsOutpatient treatment facilitiesTotal treatment costsCost of treatmentCost-effective ratioComputer-delivered interventionNet benefit analysisHealthcare utilizationCost-effective additionClinical trialsTreatment protocolCriminal justice involvementTraditional therapiesTreatment terminationTo the Editor: Our response to “Substance use improvement depends on Race/Ethnicity: Outpatient treatment disparities observed in a large US national sample”
Jordan A, Nich C, Babuscio T, Quainoo S, Carroll K. To the Editor: Our response to “Substance use improvement depends on Race/Ethnicity: Outpatient treatment disparities observed in a large US national sample”. Drug And Alcohol Dependence 2021, 223: 108670. PMID: 33812693, DOI: 10.1016/j.drugalcdep.2021.108670.Peer-Reviewed Original Research
2020
A feasibility study providing substance use treatment in the Black church
Jordan A, Babuscio T, Nich C, Carroll KM. A feasibility study providing substance use treatment in the Black church. Journal Of Substance Use And Addiction Treatment 2020, 124: 108218. PMID: 33771290, DOI: 10.1016/j.jsat.2020.108218.Peer-Reviewed Original ResearchConceptsTechnology-based treatmentsClinical trialsSUD treatmentBlack adultsNonrandomized feasibility studyUrine toxicology screenHealth care disparitiesEvidence-based interventionsDSM-5 criteriaAdequate numberCognitive behavioral therapyDisseminable strategyUndertreated populationToxicology screenCurrent SUDCare disparitiesHealth advisorsBehavioral therapySubstance useMean numberTreatmentHigh uptakeFeasibility studyCBT4CBTTrialsMeasurement invariance of the Barratt Impulsiveness Scale across black and white adults with cocaine use disorder
Haeny AM, Kiluk BD, Nich C, LaPaglia DM, Carroll KM. Measurement invariance of the Barratt Impulsiveness Scale across black and white adults with cocaine use disorder. Addictive Behaviors 2020, 114: 106721. PMID: 33162231, PMCID: PMC7802511, DOI: 10.1016/j.addbeh.2020.106721.Peer-Reviewed Original ResearchConceptsBarratt Impulsiveness ScaleHigher motor impulsivenessCocaine use disorderMeasurement invarianceMotor impulsivenessImpulsiveness ScaleBlack subsampleUse disordersDays abstinentMulti-group confirmatory factor analysisTreatment retentionCocaine abuse/dependenceCocaine treatment outcomesFactor analysisConfirmatory factor analysisAbuse/dependenceImpulsivityCocaine-negative urinesImpulsivenessBivariate correlationsWhite subsampleAbstinentOverall sampleTotal sampleAdultsShort- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders
Roos CR, Carroll KM, Nich C, Frankforter T, Kiluk BD. Short- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders. Drug And Alcohol Dependence 2020, 212: 108044. PMID: 32422538, PMCID: PMC7293942, DOI: 10.1016/j.drugalcdep.2020.108044.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyComputerized cognitive behavioral therapyPerson cognitive-behavioural therapySubstance use disordersMediation effectAlcohol use disorderComputer-delivered cognitive behavioural therapyUse disordersSame mediation effectSubstance-related copingCoping Strategies ScaleSignificant mediation effectMechanisms of changeMediational modelCoping skillsStrategies ScaleCBT4CBTStatistical mediatorCopingDrug use disordersSubstance useHeavy drinkingDisordersLong-term changesLong-term increase