‘Intention-to-treat’ meets ‘missing data’: implications of alternate strategies for analyzing clinical trials data
Nich C, Carroll KM. ‘Intention-to-treat’ meets ‘missing data’: implications of alternate strategies for analyzing clinical trials data. Drug And Alcohol Dependence 2002, 68: 121-130. PMID: 12234641, PMCID: PMC3651592, DOI: 10.1016/s0376-8716(02)00111-4.Peer-Reviewed Original ResearchConceptsEffectiveness of treatmentTreat analysisClinical trialsRandomized clinical trialsClinical trial dataStudy treatmentProtocol violationsTreat strategyTreatment retentionPoint of dropoutTime-varying covariatesTrial dataCocaine dependenceIntended durationParticipant dropoutRelative efficacyTrialsTreatmentMultiple analytic strategiesRetention outcomesDurationFull durationStrategy 1Analytic strategiesSubstantial levels