2016
Carvedilol does not reduce cocaine use in methadone-maintained cocaine users
Sofuoglu M, Poling J, Babuscio T, Gonsai K, Severino K, Nich C, Carroll KM. Carvedilol does not reduce cocaine use in methadone-maintained cocaine users. Journal Of Substance Use And Addiction Treatment 2016, 73: 63-69. PMID: 28017186, PMCID: PMC5193370, DOI: 10.1016/j.jsat.2016.11.005.Peer-Reviewed Original ResearchConceptsEfficacy of carvedilolCocaine-positive urinesSignificant group differencesCocaine use disorderCocaine useOpioid usePositive urineGroup differencesOpioid-positive urinesCAR groupMain outcome measuresUrine drug screeningOpioid-dependent participantsSelf-reported drug useSelf-reported daysOverall treatment effectCocaine-dependent participantsTreatment armsAdrenergic blockersTreatment responseOutcome measuresPlaceboWithdrawal severityStudy participationTreatment retention
2014
Toward empirical identification of a clinically meaningful indicator of treatment outcome: Features of candidate indicators and evaluation of sensitivity to treatment effects and relationship to one year follow up cocaine use outcomes
Carroll KM, Kiluk BD, Nich C, DeVito EE, Decker S, LaPaglia D, Duffey D, Babuscio TA, Ball SA. Toward empirical identification of a clinically meaningful indicator of treatment outcome: Features of candidate indicators and evaluation of sensitivity to treatment effects and relationship to one year follow up cocaine use outcomes. Drug And Alcohol Dependence 2014, 137: 3-19. PMID: 24556275, PMCID: PMC4042667, DOI: 10.1016/j.drugalcdep.2014.01.012.Peer-Reviewed Original Research
2010
Cognitive Function and Treatment Response in a Randomized Clinical Trial of Computer-Based Training in Cognitive-Behavioral Therapy
Carroll KM, Kiluk BD, Nich C, Babuscio TA, Brewer JA, Potenza MN, Ball SA, Martino S, Rounsaville BJ, Lejuez CW. Cognitive Function and Treatment Response in a Randomized Clinical Trial of Computer-Based Training in Cognitive-Behavioral Therapy. Substance Use & Misuse 2010, 46: 23-34. PMID: 21190403, PMCID: PMC3083447, DOI: 10.3109/10826084.2011.521069.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyCognitive functionComputer-assisted cognitive behavioral therapyComputer-assisted versionCognitive demandsCognitive functioningRisk takingPoor substanceSubstance usersHomework assignmentsHigh levelsClinical trialsSecondary analysisFunctioningRandomized clinical trialsParticipantsTreatment responseTakingTrainingSessionsSuch patients
1997
Variability in treatment-seeking cocaine abusers: implications for clinical pharmacotherapy trials.
Carroll KM, Nich C, Rounsaville BJ. Variability in treatment-seeking cocaine abusers: implications for clinical pharmacotherapy trials. NIDA Research Monograph 1997, 175: 137-57. PMID: 9467796.Peer-Reviewed Original ResearchConceptsPatient-treatment interactionsTreatment responseCocaine abusersClinical pharmacotherapy trialsChallenging patient populationEffective pharmacological interventionsStudy sampleSpecific treatment strategiesTreatment-seeking cocaine abusersPatient populationPharmacotherapy trialsMedication effectsNew medicationsPharmacologic agentsTreatment responsivenessPharmacological interventionsPharmacotherapy researchTreatment strategiesLarger sample sizeCocaine dependenceComparison of findingsTreatment seekingStandardized assessmentSimple main effectsInconsistent findings
1995
Differential Symptom Reduction in Depressed Cocaine Abusers Treated with Psychotherapy and Pharmacotherapy
CARROLL K, NICH C, ROUNSAVILLE B. Differential Symptom Reduction in Depressed Cocaine Abusers Treated with Psychotherapy and Pharmacotherapy. The Journal Of Nervous And Mental Disease 1995, 183: 251-259. PMID: 7714514, DOI: 10.1097/00005053-199504000-00012.Peer-Reviewed Original ResearchConceptsDepressive symptomsSymptom reductionCocaine abusersTrial of desipramineRelapse prevention treatmentSupportive clinical managementGreater reductionEuthymic subgroupPsychotherapy conditionsDesipramine treatmentEffective antidepressantDepressed subgroupClinical managementCognitive-behavioral treatmentTreatment responsePrevention treatmentCocaine outcomesAmbulatory cocaine abusersDepressive symptomatologyCocaine useCocaine addictsConsecutive abstinence