2023
Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population
Edelman E, Rojas-Perez O, Nich C, Corvino J, Frankforter T, Gordon D, Jordan A, Paris, Jr M, Weimer M, Yates B, Williams E, Kiluk B. Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population. Addiction Science & Clinical Practice 2023, 18: 55. PMID: 37726823, PMCID: PMC10510167, DOI: 10.1186/s13722-023-00407-9.Peer-Reviewed Original ResearchConceptsPost-hospital dischargeCognitive behavioral therapySelf-reported alcohol useBrief Negotiation InterviewUse disordersAlcohol use outcomesComputer-based trainingDays post-hospital dischargeAlcohol use disorderBehavioral therapyInitiation of medicationHealth care utilizationHealth promotion advocatesTreatment engagementUse outcomesAlcohol useSecondary outcomesHospitalized patientsPrimary outcomeCare utilizationClinical trialsAcademic hospitalExploratory outcomesAUDProcess evaluation
2018
Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial.
Carroll KM, Nich C, DeVito EE, Shi JM, Sofuoglu M. Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial. The Journal Of Clinical Psychiatry 2018, 79: 17m11669. PMID: 29286595, PMCID: PMC5866530, DOI: 10.4088/jcp.17m11669.Peer-Reviewed Original ResearchConceptsComputerized cognitive behavioral therapyStandard methadone treatmentCocaine use outcomesBenefits of galantamineMethadone treatmentCognitive behavioral therapyCognitive functionUse outcomesCommunity-based methadone maintenance programCocaine useStandard methadone maintenance treatmentBehavioral therapyUrine toxicology screenMethadone maintenance treatmentMethadone maintenance programCocaine treatment outcomesNicotinic acetylcholine receptorsCognitive functioningCocaine use disorderMethadone dosingSecondary outcomesToxicology screenMaintenance treatmentClinical trialsMedication administration
2016
A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence
Carroll KM, Nich C, Petry NM, Eagan DA, Shi JM, Ball SA. A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence. Drug And Alcohol Dependence 2016, 160: 135-142. PMID: 26817621, PMCID: PMC4767616, DOI: 10.1016/j.drugalcdep.2015.12.036.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyCocaine outcomesCocaine dependenceCombination of CMDouble-blind clinical trialBehavioral therapyCommunity-based outpatient clinicsUrine sample testingBlind clinical trialSustained treatment effectContingency managementDSM-IV criteriaRandomized factorial trialCurrent cocaine dependenceWeekly individual sessionsCocaine use disorderSecondary outcomesPrimary outcomeYear followOutpatient clinicAddition of disulfiramClinical trialsUse disordersCBT treatmentFactorial trial
2013
An exploratory randomized controlled trial of a novel high-school-based smoking cessation intervention for adolescent smokers using abstinence–contingent incentives and cognitive behavioral therapy
Krishnan-Sarin S, Cavallo DA, Cooney JL, Schepis TS, Kong G, Liss TB, Liss AK, McMahon TJ, Nich C, Babuscio T, Rounsaville BJ, Carroll KM. An exploratory randomized controlled trial of a novel high-school-based smoking cessation intervention for adolescent smokers using abstinence–contingent incentives and cognitive behavioral therapy. Drug And Alcohol Dependence 2013, 132: 346-351. PMID: 23523130, PMCID: PMC3748248, DOI: 10.1016/j.drugalcdep.2013.03.002.Peer-Reviewed Original ResearchConceptsSmoking cessation interventionCognitive behavioral therapyAbstinence-contingent incentivesAdolescent smokersCessation interventionsBehavioral therapyCigarette useEffective smoking cessation interventionsUrine cotinine levelsPoint prevalence abstinenceShort-term abstinenceSecondary outcomesCotinine levelsPrimary outcomeCessation treatmentCessation barriersCessation skillsFirst cigaretteFollow-upSmokersHigher abstinenceSurvival analysisNovel interventionsFour weeksHigh school
2007
Naltrexone and Disulfiram in Patients With Alcohol Dependence and Current Depression
Petrakis I, Ralevski E, Nich C, Levinson C, Carroll K, Poling J, Rounsaville B. Naltrexone and Disulfiram in Patients With Alcohol Dependence and Current Depression. Journal Of Clinical Psychopharmacology 2007, 27: 160-165. PMID: 17414239, DOI: 10.1097/jcp.0b13e3180337fcb.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DeterrentsAlcoholismBipolar DisorderCocaine-Related DisordersComorbidityConnecticutDepressive Disorder, MajorDisulfiramDouble-Blind MethodDrug Therapy, CombinationFemaleGamma-GlutamyltransferaseGastrointestinal DiseasesHumansMaleMassachusettsMiddle AgedNaltrexoneNarcotic AntagonistsPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaStress Disorders, Post-TraumaticTreatment OutcomeVeteransConceptsPsychiatric symptomsAlcohol dependenceAlcohol use outcomesMajor depressionPsychiatric disordersVeterans Administration Outpatient ClinicHamilton Depression Rating ScaleAxis I psychiatric disordersCommon co-occurring disordersDouble-blind randomizationUse outcomesGamma-glutamyltransferase levelsDepression Rating ScaleFourth Edition criteriaDiagnosis of depressionCo-occurring disordersSpecific psychiatric symptomsTreatment of alcoholismAlcohol use disorderOpen randomizationAdverse eventsMedication groupSecondary outcomesPrimary outcomeMedication treatment
2005
Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders
Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Rounsaville B, Group V. Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders. Biological Psychiatry 2005, 57: 1128-1137. PMID: 15866552, DOI: 10.1016/j.biopsych.2005.02.016.Peer-Reviewed Original ResearchConceptsPsychiatric disordersAlcohol dependenceVeterans Administration Outpatient ClinicAxis I psychiatric disordersComorbid psychiatric disordersUse of disulfiramTreatment of alcoholismEvent Monitoring SystemAlcohol-dependent individualsActive medicationAdverse eventsSecondary outcomesPrimary outcomeMedication complianceOutpatient clinicSignificant group differencesGGT levelsMedication studiesPsychiatric symptomsAlcohol consumptionNaltrexoneAlcohol cravingDrug AdministrationConsecutive weeksPlacebo