2019
Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder
DeVito EE, Carroll KM, Babuscio T, Nich C, Sofuoglu M. Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder. Journal Of Substance Use And Addiction Treatment 2019, 107: 29-37. PMID: 31757262, PMCID: PMC6918721, DOI: 10.1016/j.jsat.2019.08.009.Peer-Reviewed Original ResearchConceptsCocaine use disorderSignificant treatment group differencesUse disordersEfficacy of galantamineTreatment-seeking cocaine usersCurrent cocaine use disordersGroup differencesCocaine use outcomesSample of individualsTreatment group differencesComorbid opioid use disorderMethadone-maintained individualsMemory capacityAbstinent individualsCocaine useCognitive improvementCognitive outcomesCocaine use reductionCognitive functionUse outcomesCocaine usersGalantamine groupIndividualsDisordersInitial promise
2016
Alexithymia and Addiction: A Review and Preliminary Data Suggesting Neurobiological Links to Reward/Loss Processing
Morie KP, Yip SW, Nich C, Hunkele K, Carroll KM, Potenza MN. Alexithymia and Addiction: A Review and Preliminary Data Suggesting Neurobiological Links to Reward/Loss Processing. Current Addiction Reports 2016, 3: 239-248. PMID: 27695665, PMCID: PMC5040368, DOI: 10.1007/s40429-016-0097-8.Peer-Reviewed Original ResearchReward/loss processingSubstance use disordersLoss processingRole of alexithymiaPreliminary fMRI dataUse disordersCocaine-dependent individualsEmotional awarenessNeural correlatesReward anticipationNeurobiological correlatesAlexithymiaNeurobiological linkFMRI dataSubstance useSubstance dependenceCocaine dependenceAddictionCorrelatesIndividualsDisordersProcessingAnticipationImpairment
2009
Mindfulness Training and Stress Reactivity in Substance Abuse: Results from a Randomized, Controlled Stage I Pilot Study
Brewer JA, Sinha R, Chen JA, Michalsen RN, Babuscio TA, Nich C, Grier A, Bergquist KL, Reis DL, Potenza MN, Carroll KM, Rounsaville BJ. Mindfulness Training and Stress Reactivity in Substance Abuse: Results from a Randomized, Controlled Stage I Pilot Study. Substance Abuse 2009, 30: 306-317. PMID: 19904666, PMCID: PMC3045038, DOI: 10.1080/08897070903250241.Peer-Reviewed Original ResearchConceptsSubstance use disordersCognitive behavioral therapyUse disordersDrug useStress reactivityMindfulness trainingCocaine use disorderTreatment satisfactionOutpatient settingStage IStress provocationBehavioral therapySubstance abuseTreatment acceptabilityPilot studySubstance useTreatmentDisordersProvocationPhysiological indicesRandomizedTherapyStudyIndividualsWeekly
1999
‘Research’ versus ‘real-world’ patients: representativeness of participants in clinical trials of treatments for cocaine dependence
Carroll K, Nich C, McLellan A, McKay J, Rounsaville B. ‘Research’ versus ‘real-world’ patients: representativeness of participants in clinical trials of treatments for cocaine dependence. Drug And Alcohol Dependence 1999, 54: 171-177. PMID: 10217557, DOI: 10.1016/s0376-8716(98)00161-6.Peer-Reviewed Original ResearchConceptsClinical trialsCocaine dependenceClinical settingRegular clinical settingRigorous clinical trialsOutpatient clinical settingLarge national databaseRepresentativeness of participantsChallenging patientsResearch patientsClinical practiceMild formPatientsSubstance dependenceNational databaseTrialsRepresentativeness of subjectsLimited external validitySubjectsTreatmentExternal validityCocaine problemsIndividualsSetting