One‐year follow‐up of disulfiram and psychotherapy for cocaine‐alcohol users: sustained effects of treatment
Carroll K, Nich C, Ball S, McCance E, Frankforter T, Rounsaville B. One‐year follow‐up of disulfiram and psychotherapy for cocaine‐alcohol users: sustained effects of treatment. Addiction 2000, 95: 1335-1349. PMID: 11048353, DOI: 10.1046/j.1360-0443.2000.95913355.x.Peer-Reviewed Original ResearchConceptsCognitive-behavioral treatmentTwelve-step facilitationInitiation of abstinenceAlcohol useSubstance abuse treatment centersFrequency of cocaineAlcohol-dependent individualsClinical managementMain effectBrief treatmentEfficacy of disulfiramUrine toxicology screenCessation of treatmentBreathalyzer testEnd of treatmentOutcomes 1 yearAbstinencePercentage of daysEffect of treatmentCocaineLong-term benefitsToxicology screenTreatment centersBetter outcomesBrief periodDisulfiram treatment for cocaine dependence in methadone‐maintained opioid addicts
Petrakis IL, Carroll KM, Nich C, Gordon LT, McCance-Katz EF, Frankforter T, Rounsaville BJ. Disulfiram treatment for cocaine dependence in methadone‐maintained opioid addicts. Addiction 2000, 95: 219-228. PMID: 10723850, DOI: 10.1046/j.1360-0443.2000.9522198.x.Peer-Reviewed Original ResearchConceptsCo-morbid alcohol abuseOpioid addictsAlcohol abuseCocaine abuseCocaine dependenceAlcohol useEfficacy of disulfiramExcess of dopamineUrine toxicology screenPlacebo-controlled trialPrimary outcome measureMethadone maintenance treatmentOpioid-dependent subjectsRe-uptake inhibitorsMethadone maintenance clinicsSynthesis of norepinephrineFrequency of cocaineStudy medicationToxicology screenComorbid alcoholMaintenance treatmentPoor prognosisEffective pharmacotherapyDisulfiram treatmentMaintenance clinics