2004
Sex differences in cocaine-dependent individuals' response to disulfiram treatment
Nich C, McCance-Katz EF, Petrakis IL, Cubells JF, Rounsaville BJ, Carroll KM. Sex differences in cocaine-dependent individuals' response to disulfiram treatment. Addictive Behaviors 2004, 29: 1123-1128. PMID: 15236812, PMCID: PMC3680597, DOI: 10.1016/j.addbeh.2004.03.004.Peer-Reviewed Original ResearchConceptsDisulfiram treatmentDopamine-mediated responsesDrug-free urine specimensRandomized clinical trialsCocaine-dependent subjectsSex-based responsesDays of abstinenceSex differencesPrimary outcomeClinical trialsTreatment interactionUrine specimensBetter outcomesCocaine dependenceAlcohol useIntermediate outcomesDisulfiramSexOutcomesTreatmentSignificant sexIndividual responsesPossible mechanismResponseDifferential response
2000
Disulfiram treatment for cocaine dependence in methadone‐maintained opioid addicts
Petrakis IL, Carroll KM, Nich C, Gordon LT, McCance-Katz EF, Frankforter T, Rounsaville BJ. Disulfiram treatment for cocaine dependence in methadone‐maintained opioid addicts. Addiction 2000, 95: 219-228. PMID: 10723850, DOI: 10.1046/j.1360-0443.2000.9522198.x.Peer-Reviewed Original ResearchConceptsCo-morbid alcohol abuseOpioid addictsAlcohol abuseCocaine abuseCocaine dependenceAlcohol useEfficacy of disulfiramExcess of dopamineUrine toxicology screenPlacebo-controlled trialPrimary outcome measureMethadone maintenance treatmentOpioid-dependent subjectsRe-uptake inhibitorsMethadone maintenance clinicsSynthesis of norepinephrineFrequency of cocaineStudy medicationToxicology screenComorbid alcoholMaintenance treatmentPoor prognosisEffective pharmacotherapyDisulfiram treatmentMaintenance clinics
1998
Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram
Carroll KM, Nich C, Ball SA, McCance E, Rounsavile BJ. Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram. Addiction 1998, 93: 713-727. PMID: 9692270, DOI: 10.1046/j.1360-0443.1998.9357137.x.Peer-Reviewed Original ResearchConceptsCognitive-behavioral treatmentAlcohol useClinical managementCocaine useConcurrent alcohol abuseDrug use disordersTreatment of cocaineCo-morbid disordersPromising treatment strategySubstance abuse treatment centersTreatment-seeking cocaine abusersUrine toxicologyDrug-dependent individualsContinuous abstinenceDisulfiram treatmentStep FacilitationTreatment strategiesCocaine-dependent individualsAlcohol abuseAlcohol abusersUse disordersTreatment centersSupportive psychotherapyAlcohol dependenceActive psychotherapy