2022
Modafinil does not reduce cocaine use in methadone-maintained individuals
DeVito EE, Poling J, Babuscio T, Nich C, Carroll KM, Sofuoglu M. Modafinil does not reduce cocaine use in methadone-maintained individuals. Drug And Alcohol Dependence Reports 2022, 2: 100032. PMID: 36310662, PMCID: PMC9615926, DOI: 10.1016/j.dadr.2022.100032.Peer-Reviewed Original ResearchCocaine use disorderCocaine use outcomesOpioid useCognitive behavioral therapyContingency managementCocaine dependenceCognitive functionMethadone-maintained individualsUse outcomesEfficacy of modafinilSelf-reported abstinenceTreatment of CUDStimulant-like effectsPlatform treatmentPercentage of urinesPercent of daysDual opioidModafinil treatmentUse disordersPotential efficacyCocaine useModafinilPlaceboMinimal reportsBehavioral therapy
2019
Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder
DeVito EE, Carroll KM, Babuscio T, Nich C, Sofuoglu M. Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder. Journal Of Substance Use And Addiction Treatment 2019, 107: 29-37. PMID: 31757262, PMCID: PMC6918721, DOI: 10.1016/j.jsat.2019.08.009.Peer-Reviewed Original ResearchConceptsCocaine use disorderSignificant treatment group differencesUse disordersEfficacy of galantamineTreatment-seeking cocaine usersCurrent cocaine use disordersGroup differencesCocaine use outcomesSample of individualsTreatment group differencesComorbid opioid use disorderMethadone-maintained individualsMemory capacityAbstinent individualsCocaine useCognitive improvementCognitive outcomesCocaine use reductionCognitive functionUse outcomesCocaine usersGalantamine groupIndividualsDisordersInitial promise
2018
Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial.
Carroll KM, Nich C, DeVito EE, Shi JM, Sofuoglu M. Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial. The Journal Of Clinical Psychiatry 2018, 79: 17m11669. PMID: 29286595, PMCID: PMC5866530, DOI: 10.4088/jcp.17m11669.Peer-Reviewed Original ResearchConceptsComputerized cognitive behavioral therapyStandard methadone treatmentCocaine use outcomesBenefits of galantamineMethadone treatmentCognitive behavioral therapyCognitive functionUse outcomesCommunity-based methadone maintenance programCocaine useStandard methadone maintenance treatmentBehavioral therapyUrine toxicology screenMethadone maintenance treatmentMethadone maintenance programCocaine treatment outcomesNicotinic acetylcholine receptorsCognitive functioningCocaine use disorderMethadone dosingSecondary outcomesToxicology screenMaintenance treatmentClinical trialsMedication administration
2010
Cognitive Function and Treatment Response in a Randomized Clinical Trial of Computer-Based Training in Cognitive-Behavioral Therapy
Carroll KM, Kiluk BD, Nich C, Babuscio TA, Brewer JA, Potenza MN, Ball SA, Martino S, Rounsaville BJ, Lejuez CW. Cognitive Function and Treatment Response in a Randomized Clinical Trial of Computer-Based Training in Cognitive-Behavioral Therapy. Substance Use & Misuse 2010, 46: 23-34. PMID: 21190403, PMCID: PMC3083447, DOI: 10.3109/10826084.2011.521069.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyCognitive functionComputer-assisted cognitive behavioral therapyComputer-assisted versionCognitive demandsCognitive functioningRisk takingPoor substanceSubstance usersHomework assignmentsHigh levelsClinical trialsSecondary analysisFunctioningRandomized clinical trialsParticipantsTreatment responseTakingTrainingSessionsSuch patientsRelationship of cognitive function and the acquisition of coping skills in computer assisted treatment for substance use disorders
Kiluk BD, Nich C, Carroll KM. Relationship of cognitive function and the acquisition of coping skills in computer assisted treatment for substance use disorders. Drug And Alcohol Dependence 2010, 114: 169-176. PMID: 21050679, PMCID: PMC3046302, DOI: 10.1016/j.drugalcdep.2010.09.019.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyCognitive functioningCoping skillsBehavioral therapySubstance useCoping skills trainingMeasures of IQSubstance-dependent individualsSignificant indirect effectSubstance use outcomesChronic substance useNeuropsychological measuresNeuropsychological factorsSubstance use disordersComputerized versionHigher IQSkills trainingCognitive functionLower IQLittle previous researchIQDependent individualsPoor functioningUse outcomesCognitive impairment